Epstein-Barr virus plays little role in cervical carcinogenesis in Korean women

S. S. Seo, W. H. Kim, Y. S. Song, S. H. Kim, J. W. Kim, N. H. Park, S. B. Kang, H. P. Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We examined whether Epstein-Barr virus (EBV) infection plays a role in cervical carcinogenesis in Korean women. EBV infection was examined using polymerase chain reaction (PCR) with two different primer pairs flanking the BamHI "W" fragment of EBV and by EBV-encoded small RNAs (EBER) in situ hybridization in various histologic types of cervical cancer, including 17 cases of squamous cell carcinoma, 36 cases of adenocarcinoma, and 3 cases of small-cell carcinoma. We also evaluated 20 cases of cervical intraepithelial neoplasia and 20 cases of normal uterine cervix. One case of squamous cell carcinoma and three cases of cervical intraepithelial neoplasia were positive for EBV DNA using PCR, but EBER in situ hybridization analysis showed that none of the PCR-positive cases expressed EBER. EBV DNA was not found using PCR in any of the 20 normal uterine cervices. From our results, EBV infection does not seem to play a role in cervical carcinogenesis in Korean women.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume15
Issue number2
DOIs
StatePublished - 1 Mar 2005

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Human Herpesvirus 4
Carcinogenesis
Epstein-Barr Virus Infections
Polymerase Chain Reaction
Cervical Intraepithelial Neoplasia
RNA
Cervix Uteri
In Situ Hybridization
Squamous Cell Carcinoma
Small Cell Carcinoma
Uterine Cervical Neoplasms
Adenocarcinoma
DNA

Keywords

  • Cervical carcinoma
  • Epstein-Barr virus
  • Korean women

Cite this

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title = "Epstein-Barr virus plays little role in cervical carcinogenesis in Korean women",
abstract = "We examined whether Epstein-Barr virus (EBV) infection plays a role in cervical carcinogenesis in Korean women. EBV infection was examined using polymerase chain reaction (PCR) with two different primer pairs flanking the BamHI {"}W{"} fragment of EBV and by EBV-encoded small RNAs (EBER) in situ hybridization in various histologic types of cervical cancer, including 17 cases of squamous cell carcinoma, 36 cases of adenocarcinoma, and 3 cases of small-cell carcinoma. We also evaluated 20 cases of cervical intraepithelial neoplasia and 20 cases of normal uterine cervix. One case of squamous cell carcinoma and three cases of cervical intraepithelial neoplasia were positive for EBV DNA using PCR, but EBER in situ hybridization analysis showed that none of the PCR-positive cases expressed EBER. EBV DNA was not found using PCR in any of the 20 normal uterine cervices. From our results, EBV infection does not seem to play a role in cervical carcinogenesis in Korean women.",
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Epstein-Barr virus plays little role in cervical carcinogenesis in Korean women. / Seo, S. S.; Kim, W. H.; Song, Y. S.; Kim, S. H.; Kim, J. W.; Park, N. H.; Kang, S. B.; Lee, H. P.

In: International Journal of Gynecological Cancer, Vol. 15, No. 2, 01.03.2005, p. 312-318.

Research output: Contribution to journalArticle

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