Epidemiological characteristics of subsyndromal depression in late life

Dae Jong Oh, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim

Research output: Contribution to journalArticle

Abstract

Objectives: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study is to compare the prevalence, incidence and risk factors of subsyndromal depression with those of syndromal depression including major and minor depressive disorders in community-dwelling elderly individuals. Methods: In a nationwide community-based study of randomly sampled Korean elderly population aged 60 years or older (N = 6640), depression was assessed with standardized diagnostic interviews. At baseline and at 2-year and 4-year follow-ups, the authors diagnosed subsyndromal depression by the operational criteria and syndromal depression by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnostic criteria. Multivariate logistic regression analyses were conducted to identify the risk factors for incident depression. Results: The age- and gender-adjusted prevalence rate of subsyndromal depression was 9.24% (95% confidence interval = [8.54, 9.93]), which was 2.4-fold higher than that of syndromal depression. The incidence rate of subsyndromal depression was 21.70 per 1000 person-years (95% confidence interval = [19.29, 24.12]), which was fivefold higher than that of syndromal depression. The prevalence to incidence ratio of subsyndromal depression was about half that of syndromal depression. The risk for subsyndromal depression was associated with female gender, low socioeconomic status, poor social support and poor sleep quality, while that of syndromal depression was associated with old age and less exercise. Conclusion: Subsyndromal depression should be validated as a clinical diagnostic entity, at least in late life, since it has epidemiological characteristics different from those of syndromal depression.

Original languageEnglish
Pages (from-to)150-158
Number of pages9
JournalAustralian and New Zealand Journal of Psychiatry
Volume54
Issue number2
DOIs
StatePublished - 1 Feb 2020

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Depression
Incidence
Confidence Intervals
Independent Living
Major Depressive Disorder
Social Class
Diagnostic and Statistical Manual of Mental Disorders
Social Support
Sleep
Cohort Studies
Logistic Models
Regression Analysis
Prospective Studies
Interviews
Exercise

Keywords

  • Depression
  • epidemiology
  • geriatric psychiatry
  • incidence
  • risk factors

Cite this

Oh, Dae Jong ; Han, Ji Won ; Kim, Tae Hui ; Kwak, Kyung Phil ; Kim, Bong Jo ; Kim, Shin Gyeom ; Kim, Jeong Lan ; Moon, Seok Woo ; Park, Joon Hyuk ; Ryu, Seung Ho ; Youn, Jong Chul ; Lee, Dong Young ; Lee, Dong Woo ; Lee, Seok Bum ; Lee, Jung Jae ; Jhoo, Jin Hyeong ; Kim, Ki Woong. / Epidemiological characteristics of subsyndromal depression in late life. In: Australian and New Zealand Journal of Psychiatry. 2020 ; Vol. 54, No. 2. pp. 150-158.
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abstract = "Objectives: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study is to compare the prevalence, incidence and risk factors of subsyndromal depression with those of syndromal depression including major and minor depressive disorders in community-dwelling elderly individuals. Methods: In a nationwide community-based study of randomly sampled Korean elderly population aged 60 years or older (N = 6640), depression was assessed with standardized diagnostic interviews. At baseline and at 2-year and 4-year follow-ups, the authors diagnosed subsyndromal depression by the operational criteria and syndromal depression by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnostic criteria. Multivariate logistic regression analyses were conducted to identify the risk factors for incident depression. Results: The age- and gender-adjusted prevalence rate of subsyndromal depression was 9.24{\%} (95{\%} confidence interval = [8.54, 9.93]), which was 2.4-fold higher than that of syndromal depression. The incidence rate of subsyndromal depression was 21.70 per 1000 person-years (95{\%} confidence interval = [19.29, 24.12]), which was fivefold higher than that of syndromal depression. The prevalence to incidence ratio of subsyndromal depression was about half that of syndromal depression. The risk for subsyndromal depression was associated with female gender, low socioeconomic status, poor social support and poor sleep quality, while that of syndromal depression was associated with old age and less exercise. Conclusion: Subsyndromal depression should be validated as a clinical diagnostic entity, at least in late life, since it has epidemiological characteristics different from those of syndromal depression.",
keywords = "Depression, epidemiology, geriatric psychiatry, incidence, risk factors",
author = "Oh, {Dae Jong} and Han, {Ji Won} and Kim, {Tae Hui} and Kwak, {Kyung Phil} and Kim, {Bong Jo} and Kim, {Shin Gyeom} and Kim, {Jeong Lan} and Moon, {Seok Woo} and Park, {Joon Hyuk} and Ryu, {Seung Ho} and Youn, {Jong Chul} and Lee, {Dong Young} and Lee, {Dong Woo} and Lee, {Seok Bum} and Lee, {Jung Jae} and Jhoo, {Jin Hyeong} and Kim, {Ki Woong}",
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Oh, DJ, Han, JW, Kim, TH, Kwak, KP, Kim, BJ, Kim, SG, Kim, JL, Moon, SW, Park, JH, Ryu, SH, Youn, JC, Lee, DY, Lee, DW, Lee, SB, Lee, JJ, Jhoo, JH & Kim, KW 2020, 'Epidemiological characteristics of subsyndromal depression in late life', Australian and New Zealand Journal of Psychiatry, vol. 54, no. 2, pp. 150-158. https://doi.org/10.1177/0004867419879242

Epidemiological characteristics of subsyndromal depression in late life. / Oh, Dae Jong; Han, Ji Won; Kim, Tae Hui; Kwak, Kyung Phil; Kim, Bong Jo; Kim, Shin Gyeom; Kim, Jeong Lan; Moon, Seok Woo; Park, Joon Hyuk; Ryu, Seung Ho; Youn, Jong Chul; Lee, Dong Young; Lee, Dong Woo; Lee, Seok Bum; Lee, Jung Jae; Jhoo, Jin Hyeong; Kim, Ki Woong.

In: Australian and New Zealand Journal of Psychiatry, Vol. 54, No. 2, 01.02.2020, p. 150-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Epidemiological characteristics of subsyndromal depression in late life

AU - Oh, Dae Jong

AU - Han, Ji Won

AU - Kim, Tae Hui

AU - Kwak, Kyung Phil

AU - Kim, Bong Jo

AU - Kim, Shin Gyeom

AU - Kim, Jeong Lan

AU - Moon, Seok Woo

AU - Park, Joon Hyuk

AU - Ryu, Seung Ho

AU - Youn, Jong Chul

AU - Lee, Dong Young

AU - Lee, Dong Woo

AU - Lee, Seok Bum

AU - Lee, Jung Jae

AU - Jhoo, Jin Hyeong

AU - Kim, Ki Woong

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Objectives: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study is to compare the prevalence, incidence and risk factors of subsyndromal depression with those of syndromal depression including major and minor depressive disorders in community-dwelling elderly individuals. Methods: In a nationwide community-based study of randomly sampled Korean elderly population aged 60 years or older (N = 6640), depression was assessed with standardized diagnostic interviews. At baseline and at 2-year and 4-year follow-ups, the authors diagnosed subsyndromal depression by the operational criteria and syndromal depression by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnostic criteria. Multivariate logistic regression analyses were conducted to identify the risk factors for incident depression. Results: The age- and gender-adjusted prevalence rate of subsyndromal depression was 9.24% (95% confidence interval = [8.54, 9.93]), which was 2.4-fold higher than that of syndromal depression. The incidence rate of subsyndromal depression was 21.70 per 1000 person-years (95% confidence interval = [19.29, 24.12]), which was fivefold higher than that of syndromal depression. The prevalence to incidence ratio of subsyndromal depression was about half that of syndromal depression. The risk for subsyndromal depression was associated with female gender, low socioeconomic status, poor social support and poor sleep quality, while that of syndromal depression was associated with old age and less exercise. Conclusion: Subsyndromal depression should be validated as a clinical diagnostic entity, at least in late life, since it has epidemiological characteristics different from those of syndromal depression.

AB - Objectives: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study is to compare the prevalence, incidence and risk factors of subsyndromal depression with those of syndromal depression including major and minor depressive disorders in community-dwelling elderly individuals. Methods: In a nationwide community-based study of randomly sampled Korean elderly population aged 60 years or older (N = 6640), depression was assessed with standardized diagnostic interviews. At baseline and at 2-year and 4-year follow-ups, the authors diagnosed subsyndromal depression by the operational criteria and syndromal depression by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnostic criteria. Multivariate logistic regression analyses were conducted to identify the risk factors for incident depression. Results: The age- and gender-adjusted prevalence rate of subsyndromal depression was 9.24% (95% confidence interval = [8.54, 9.93]), which was 2.4-fold higher than that of syndromal depression. The incidence rate of subsyndromal depression was 21.70 per 1000 person-years (95% confidence interval = [19.29, 24.12]), which was fivefold higher than that of syndromal depression. The prevalence to incidence ratio of subsyndromal depression was about half that of syndromal depression. The risk for subsyndromal depression was associated with female gender, low socioeconomic status, poor social support and poor sleep quality, while that of syndromal depression was associated with old age and less exercise. Conclusion: Subsyndromal depression should be validated as a clinical diagnostic entity, at least in late life, since it has epidemiological characteristics different from those of syndromal depression.

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KW - epidemiology

KW - geriatric psychiatry

KW - incidence

KW - risk factors

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