Epidemiologic and clinical features of anaphylaxis in Korea

Min Suk Yang, So Hee Lee, Tae Wan Kim, Jae Woo Kwon, Sang Min Lee, Sae Hoon Kim, Hyouk Soo Kwon, Chang Han Park, Heung Woo Park, Sun Sin Kim, Sang Heon Cho, Kyung Up Min, You Young Kim, Yoon Seok Chang

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Abstract

Background: Little is known about the characteristics of anaphylaxis in Korea or even in Asia. Objective: To evaluate the incidence of anaphylaxis and the clinical features of patients with anaphylaxis in a Korean tertiary care hospital. Methods: We performed a retrospective review from January 1, 2000, through July 31, 2006, of 138 patients with anaphylaxis, including inpatients, outpatients, and emergency department visitors, in the Seoul National University Hospital. Results: Among 978,146 patients, 138 (0.014%) had anaphylaxis. Two cardiopulmonary resuscitations were performed and 1 death occurred. The total mortality rate of anaphylactic patients was 0.0001%. The causes of anaphylaxes were drug (35.3%), food (21.3%), food-dependent exercise-induced (13.2%), idiopathic (13.2%), insect stings (11.8%), exercise induced (2.9%), blood products (1.5%), and latex (0.7%). Radiocontrast media and buckwheat were the leading causes of drug and food anaphylaxis, respectively. The organs most frequently involved in the anaphylaxis were cutaneous (95.7%), cardiovascular (76.8%), and respiratory (74.6%). The most common manifestations were dyspnea (71.3%), urticaria (81.9%), and angioedema (69.4%). Three of 138 patients (2.2%) had biphasic reactions. Conclusions: The incidence, mortality rate, and clinical features of Korean patients with anaphylaxis were similar to rates for patients from other countries, despite some differences in causative agents.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalAnnals of Allergy, Asthma and Immunology
Volume100
Issue number1
DOIs
StatePublished - Jan 2008

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