Endovascular management of multiple intracranial dural arteriovenous fistulas

Ching Chang Chen, Young Dae Cho, Dong Hyun Yoo, Jusun Moon, Jeongjun Lee, Hyun-Seung Kang, Jeong Eun Kim, Won Sang Cho, Moon Hee Han

Research output: Contribution to journalArticle

Abstract

Background and purpose: Multiply occurring intracranial dural arteriovenous fistulas (dAVFs) have been documented but rarely occur, and neither pathogenesis nor prognosis is clearly understood. This study was conducted to analyze angiographic characteristics of multiple dAVFs and to chronicle our treatment experience. Methods: Between April, 2002 and January, 2018, data prospectively collected from 310 patients with intracranial dAVFs were systematically reviewed, assessing clinical and anatomic outcomes of endovascular treatment in 32 patients with multiple dAVFs (≥ 2 fistulas each). Lesions were categorized as multifocal or diffuse type, depending on presentation, and further characterized as progressive or non-progressive disease. Results: Overall, 18 patients (56.3%) experienced aggressive presentations, including intracerebral hemorrhage or venous infarction. Cortical venous reflux (CVR) was observed in 26 patients (81.3%), and sinus thrombosis or occlusion was seen in 24 (75.0%). Clinical outcomes in patients with multifocal fistulas (n = 11) were excellent (100%), marked by a moderately high rate of complete occlusion (54.5%). Those with progressive disease (n = 10) regularly displayed certain angiographic findings, namely diffuse configuration (100%), sinus thrombosis (100%), and CVR (100%). Complete anatomic obliteration was achieved in 12 patients (37.5%), and in 26 patients (81.3%), clinical outcomes were favorable. Conclusion: Multiple dAVFs are typically aggressive at presentation, given strong associations with CVR and sinus thrombosis. In diffuse-type fistulas, the potential to recur or progress is high. Although definitive treatment poses a challenge, outcomes of endovascular therapeutics may be still optimized in this setting through strategic procedural modifications and careful follow-up monitoring.

Original languageEnglish
Pages (from-to)390-397
Number of pages8
JournalJournal of Neuroradiology
Volume46
Issue number6
DOIs
StatePublished - 1 Nov 2019

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Central Nervous System Vascular Malformations
Intracranial Sinus Thrombosis
Fistula
Cerebral Hemorrhage
Venous Thrombosis
Infarction
Therapeutics

Keywords

  • Dural arteriovenous fistula
  • Endovascular
  • Multiple
  • Treatment

Cite this

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title = "Endovascular management of multiple intracranial dural arteriovenous fistulas",
abstract = "Background and purpose: Multiply occurring intracranial dural arteriovenous fistulas (dAVFs) have been documented but rarely occur, and neither pathogenesis nor prognosis is clearly understood. This study was conducted to analyze angiographic characteristics of multiple dAVFs and to chronicle our treatment experience. Methods: Between April, 2002 and January, 2018, data prospectively collected from 310 patients with intracranial dAVFs were systematically reviewed, assessing clinical and anatomic outcomes of endovascular treatment in 32 patients with multiple dAVFs (≥ 2 fistulas each). Lesions were categorized as multifocal or diffuse type, depending on presentation, and further characterized as progressive or non-progressive disease. Results: Overall, 18 patients (56.3{\%}) experienced aggressive presentations, including intracerebral hemorrhage or venous infarction. Cortical venous reflux (CVR) was observed in 26 patients (81.3{\%}), and sinus thrombosis or occlusion was seen in 24 (75.0{\%}). Clinical outcomes in patients with multifocal fistulas (n = 11) were excellent (100{\%}), marked by a moderately high rate of complete occlusion (54.5{\%}). Those with progressive disease (n = 10) regularly displayed certain angiographic findings, namely diffuse configuration (100{\%}), sinus thrombosis (100{\%}), and CVR (100{\%}). Complete anatomic obliteration was achieved in 12 patients (37.5{\%}), and in 26 patients (81.3{\%}), clinical outcomes were favorable. Conclusion: Multiple dAVFs are typically aggressive at presentation, given strong associations with CVR and sinus thrombosis. In diffuse-type fistulas, the potential to recur or progress is high. Although definitive treatment poses a challenge, outcomes of endovascular therapeutics may be still optimized in this setting through strategic procedural modifications and careful follow-up monitoring.",
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Endovascular management of multiple intracranial dural arteriovenous fistulas. / Chen, Ching Chang; Cho, Young Dae; Yoo, Dong Hyun; Moon, Jusun; Lee, Jeongjun; Kang, Hyun-Seung; Kim, Jeong Eun; Cho, Won Sang; Han, Moon Hee.

In: Journal of Neuroradiology, Vol. 46, No. 6, 01.11.2019, p. 390-397.

Research output: Contribution to journalArticle

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AU - Yoo, Dong Hyun

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AU - Han, Moon Hee

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