Abstract
BACKGROUNDAltered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to endometriosis. This study was designed to evaluate the association between the Glu298Asp polymorphism of the NOS3 and advanced stage endometriosis.METHODSThis study consisted of 299 women with advanced stage endometriosis and 459 control women without endometriosis in a Korean population. Genotyping results of the Glu298Asp polymorphism of the NOS3 were analyzed between the endometriosis and control group.RESULTSThe genotypic frequencies were significantly different between women with and without endometriosis. The frequency of the non-GG genotype (GT + TT) was higher in the endometriosis group than in the control group (P = 0.001).CONCLUSIONThese findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the NOS3 may be associated with advanced stage endometriosis in the Korean population.
| Original language | English |
|---|---|
| Pages (from-to) | 2656-2659 |
| Number of pages | 4 |
| Journal | Human Reproduction |
| Volume | 24 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2009 |
Bibliographical note
Funding Information:This study was supported by a grant (01-PJ10-PG6-01GN13-0002) from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea.
Keywords
- ENOS
- Endometriosis
- NOS3
- Polymorphism