Elastic net of polyurethane strands for sustained delivery of triamcinolone around silicone implants of various sizes

Beom Kang Huh, Byung Hwi Kim, Cho Rim Kim, Se Na Kim, Byung Ho Shin, Han Bi Ji, Seung Ho Lee, Min Ji Kim, Chan Yeong Heo, Young Bin Choy

Research output: Contribution to journalArticle

Abstract

We propose an elastic net made of a biocompatible polymer to wrap silicone implants of various sizes, which also allows for the sustained release of an anti-inflammatory drug, triamcinolone, to prevent fibrosis. For this, we first prepared a strand composed of a mixture of polyurethane and triamcinolone via electrospinning, which was then assembled to prepare the elastic drug-delivery net (DDN). The DDN was prepared to just fit for wrapping the small silicone implant sample herein, but was also able to wrap a sample 7 times as large at 72% strain due to the elastic property of polyurethane. The DDN exhibited sustained drug release for 4 weeks, the profile of which was not very different between the intact and strained DDNs. When implanted in a subcutaneous pocket in living rats, the DDN-wrapped silicone implant samples showed an obvious antifibrotic effect due to the sustained release of triamcinolone. Importantly, this effect was similar for the small and large silicone samples, both wrapped with the same DDN. Therefore, we conclude that this drug-loaded net made of an elastic, biocompatible polymer has high potential for sustained drug delivery around silicone implants manufactured in various sizes.

Original languageEnglish
Article number110565
JournalMaterials Science and Engineering C
Volume109
DOIs
StatePublished - Apr 2020

Fingerprint

Triamcinolone
Polyurethanes
silicones
Silicones
Drug delivery
strands
delivery
drugs
wrap
Polymers
Pharmaceutical Preparations
Electrospinning
Rats
fibrosis
high polymers
Anti-Inflammatory Agents
rats
elastic properties

Keywords

  • Drug delivery
  • Fibrosis
  • Polyurethane
  • Silicone implant
  • Triamcinolone

Cite this

Huh, Beom Kang ; Kim, Byung Hwi ; Kim, Cho Rim ; Kim, Se Na ; Shin, Byung Ho ; Ji, Han Bi ; Lee, Seung Ho ; Kim, Min Ji ; Heo, Chan Yeong ; Choy, Young Bin. / Elastic net of polyurethane strands for sustained delivery of triamcinolone around silicone implants of various sizes. In: Materials Science and Engineering C. 2020 ; Vol. 109.
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abstract = "We propose an elastic net made of a biocompatible polymer to wrap silicone implants of various sizes, which also allows for the sustained release of an anti-inflammatory drug, triamcinolone, to prevent fibrosis. For this, we first prepared a strand composed of a mixture of polyurethane and triamcinolone via electrospinning, which was then assembled to prepare the elastic drug-delivery net (DDN). The DDN was prepared to just fit for wrapping the small silicone implant sample herein, but was also able to wrap a sample 7 times as large at 72{\%} strain due to the elastic property of polyurethane. The DDN exhibited sustained drug release for 4 weeks, the profile of which was not very different between the intact and strained DDNs. When implanted in a subcutaneous pocket in living rats, the DDN-wrapped silicone implant samples showed an obvious antifibrotic effect due to the sustained release of triamcinolone. Importantly, this effect was similar for the small and large silicone samples, both wrapped with the same DDN. Therefore, we conclude that this drug-loaded net made of an elastic, biocompatible polymer has high potential for sustained drug delivery around silicone implants manufactured in various sizes.",
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Elastic net of polyurethane strands for sustained delivery of triamcinolone around silicone implants of various sizes. / Huh, Beom Kang; Kim, Byung Hwi; Kim, Cho Rim; Kim, Se Na; Shin, Byung Ho; Ji, Han Bi; Lee, Seung Ho; Kim, Min Ji; Heo, Chan Yeong; Choy, Young Bin.

In: Materials Science and Engineering C, Vol. 109, 110565, 04.2020.

Research output: Contribution to journalArticle

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AU - Huh, Beom Kang

AU - Kim, Byung Hwi

AU - Kim, Cho Rim

AU - Kim, Se Na

AU - Shin, Byung Ho

AU - Ji, Han Bi

AU - Lee, Seung Ho

AU - Kim, Min Ji

AU - Heo, Chan Yeong

AU - Choy, Young Bin

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AB - We propose an elastic net made of a biocompatible polymer to wrap silicone implants of various sizes, which also allows for the sustained release of an anti-inflammatory drug, triamcinolone, to prevent fibrosis. For this, we first prepared a strand composed of a mixture of polyurethane and triamcinolone via electrospinning, which was then assembled to prepare the elastic drug-delivery net (DDN). The DDN was prepared to just fit for wrapping the small silicone implant sample herein, but was also able to wrap a sample 7 times as large at 72% strain due to the elastic property of polyurethane. The DDN exhibited sustained drug release for 4 weeks, the profile of which was not very different between the intact and strained DDNs. When implanted in a subcutaneous pocket in living rats, the DDN-wrapped silicone implant samples showed an obvious antifibrotic effect due to the sustained release of triamcinolone. Importantly, this effect was similar for the small and large silicone samples, both wrapped with the same DDN. Therefore, we conclude that this drug-loaded net made of an elastic, biocompatible polymer has high potential for sustained drug delivery around silicone implants manufactured in various sizes.

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