Efficacy of intrathecal morphine for postoperative pain management following open nephrectomy

Hyun Chang Kim, Jun Yeol Bae, Tae Kyong Kim, Yunseok Jeon, Jeong Jin Min, Eui Kyoung Goo, Deok Man Hong

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: To evaluate the efficacy and safety of intrathecal morphine (ITM) for postoperative pain control in patients with renal cell carcinoma undergoing open nephrectomy. Methods: Forty-five patients scheduled for open nephrectomy were randomised to receive 300 µg ITM and intravenous patient-controlled analgesia (IV-PCA) (n = 22) or IV-PCA alone (n = 23) for postoperative analgesia. The numeric pain score (NPS), postoperative IV-PCA requirements and opioid-related complications including nausea, vomiting, dizziness, headache, and pruritus were compared between groups. Results: NPS was significantly lower in the ITM group up to 24 h postoperatively. Upon coughing, NPS at 24 h postoperatively was 50 (interquartile range (IQR) 30–60) in the ITM group and 60 (45–70) in the IV-PCA group. Cumulative morphine consumption at 72 h postoperatively was significantly lower in the ITM group compared with the IV-PCA group (20 (9–33) mg vs. 31 (21–49) mg, respectively). Opioid-related complications were similar in both groups with the exception of pruritus (ITM, 77% vs. IV-PCA, 26%). Conclusions: ITM was associated with greater analgesia without serious complications in patients undergoing open nephrectomy.

Original languageEnglish
Pages (from-to)42-53
Number of pages12
JournalJournal of International Medical Research
Volume44
Issue number1
DOIs
StatePublished - 1 Feb 2016

Keywords

  • Injections
  • morphine
  • nephrectomy
  • pain
  • postoperative
  • spinal

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