Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning

Jun Hyeok Choi, Pojeong Park, Gi Chul Baek, Su Eon Sim, Suk Jae Joshua Kang, Yeseul Lee, Seo Hee Ahn, Chae Seok Lim, Yong-Seok Lee, Graham L. Collingridge, Bong Kiun Kaang

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Abstract

Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampusdependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-Term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-Term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning.

Original languageEnglish
Article number78
JournalMolecular brain
Volume7
Issue number1
DOIs
StatePublished - 6 Nov 2014

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Neuronal Plasticity
1-Phosphatidylinositol 4-Kinase
Hippocampus
Depression
Hippocampal CA1 Region
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
Fear
Spatial Learning
Catalytic Domain
Protein Isoforms
Learning
Water
Brain

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Choi, J. H., Park, P., Baek, G. C., Sim, S. E., Kang, S. J. J., Lee, Y., ... Kaang, B. K. (2014). Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning. Molecular brain, 7(1), [78]. https://doi.org/10.1186/s13041-014-0078-6
Choi, Jun Hyeok ; Park, Pojeong ; Baek, Gi Chul ; Sim, Su Eon ; Kang, Suk Jae Joshua ; Lee, Yeseul ; Ahn, Seo Hee ; Lim, Chae Seok ; Lee, Yong-Seok ; Collingridge, Graham L. ; Kaang, Bong Kiun. / Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning. In: Molecular brain. 2014 ; Vol. 7, No. 1.
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Choi, JH, Park, P, Baek, GC, Sim, SE, Kang, SJJ, Lee, Y, Ahn, SH, Lim, CS, Lee, Y-S, Collingridge, GL & Kaang, BK 2014, 'Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning', Molecular brain, vol. 7, no. 1, 78. https://doi.org/10.1186/s13041-014-0078-6

Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning. / Choi, Jun Hyeok; Park, Pojeong; Baek, Gi Chul; Sim, Su Eon; Kang, Suk Jae Joshua; Lee, Yeseul; Ahn, Seo Hee; Lim, Chae Seok; Lee, Yong-Seok; Collingridge, Graham L.; Kaang, Bong Kiun.

In: Molecular brain, Vol. 7, No. 1, 78, 06.11.2014.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Choi, Jun Hyeok

AU - Park, Pojeong

AU - Baek, Gi Chul

AU - Sim, Su Eon

AU - Kang, Suk Jae Joshua

AU - Lee, Yeseul

AU - Ahn, Seo Hee

AU - Lim, Chae Seok

AU - Lee, Yong-Seok

AU - Collingridge, Graham L.

AU - Kaang, Bong Kiun

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