Effects of Nonsteroidal Anti-Inflammatory Drugs as Patient Controlled Analgesia on Early Bowel Function Recovery after Radical Cystectomy

Young Dong Yu, Jin Ho Hwang, Young Eun Seo, Byung Do Song, Yeon Soo Jung, Dong Hwan Lee, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee, Jong Jin Oh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study aimed to evaluate the effects of ketorolac, a commonly used non-steroidal anti-inflammatory drug (NSAID) as patient controlled intravenous infusion analgesia (PCIA) for the patients underwent radical cystectomy (RC) due to bladder cancer regarding post-operational indices of recovery. Total seventy patients who underwent radical cystectomy for the treatment of bladder cancer were included in the study. 35 patients received ketorolac as PCIA (NSAIDS group) and 35 patients had morphine infusion as PCIA (morphine group). Pain intensity, bowel function recovery and length of hospital stay were evaluated. Early postoperative complications were analyzed according to surgical types (robot RC vs. open RC). Demographics were similar between two groups. NSAIDS group showed a significant reduction in postoperative vomiting (p = 0.001), time to flatus (p = 0.028), time to first bowel movement (p = 0.001) and time to first clear liquid diet (p = 0.002) compared with morphine group. No statistically significant differences were observed between two groups regarding length of hospitalization, and postoperative complications. For 48 hours after RC, pain relief was slightly better in morphine group (p < 0.001). Both open RC and robot RC cases showed significantly better bowel function recovery with NSAIDS groups. Ketorolac as PCIA is relatively effective in pain management with better gastrointestinal recovery after RC.

Original languageEnglish
Article number4658
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - 1 Dec 2018

Fingerprint

Patient-Controlled Analgesia
Cystectomy
Recovery of Function
Anti-Inflammatory Agents
Ketorolac
Intravenous Infusions
Pharmaceutical Preparations
Analgesia
Morphine
Urinary Bladder Neoplasms
Length of Stay
Flatulence
Pain
Postoperative Nausea and Vomiting
Pain Management
Hospitalization
Demography
Diet

Cite this

Yu, Young Dong ; Hwang, Jin Ho ; Seo, Young Eun ; Song, Byung Do ; Jung, Yeon Soo ; Lee, Dong Hwan ; Hong, Sung Kyu ; Byun, Seok-Soo ; Lee, Sang Eun ; Oh, Jong Jin. / Effects of Nonsteroidal Anti-Inflammatory Drugs as Patient Controlled Analgesia on Early Bowel Function Recovery after Radical Cystectomy. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
@article{52893783b6414d558af988b310831eca,
title = "Effects of Nonsteroidal Anti-Inflammatory Drugs as Patient Controlled Analgesia on Early Bowel Function Recovery after Radical Cystectomy",
abstract = "This study aimed to evaluate the effects of ketorolac, a commonly used non-steroidal anti-inflammatory drug (NSAID) as patient controlled intravenous infusion analgesia (PCIA) for the patients underwent radical cystectomy (RC) due to bladder cancer regarding post-operational indices of recovery. Total seventy patients who underwent radical cystectomy for the treatment of bladder cancer were included in the study. 35 patients received ketorolac as PCIA (NSAIDS group) and 35 patients had morphine infusion as PCIA (morphine group). Pain intensity, bowel function recovery and length of hospital stay were evaluated. Early postoperative complications were analyzed according to surgical types (robot RC vs. open RC). Demographics were similar between two groups. NSAIDS group showed a significant reduction in postoperative vomiting (p = 0.001), time to flatus (p = 0.028), time to first bowel movement (p = 0.001) and time to first clear liquid diet (p = 0.002) compared with morphine group. No statistically significant differences were observed between two groups regarding length of hospitalization, and postoperative complications. For 48 hours after RC, pain relief was slightly better in morphine group (p < 0.001). Both open RC and robot RC cases showed significantly better bowel function recovery with NSAIDS groups. Ketorolac as PCIA is relatively effective in pain management with better gastrointestinal recovery after RC.",
author = "Yu, {Young Dong} and Hwang, {Jin Ho} and Seo, {Young Eun} and Song, {Byung Do} and Jung, {Yeon Soo} and Lee, {Dong Hwan} and Hong, {Sung Kyu} and Seok-Soo Byun and Lee, {Sang Eun} and Oh, {Jong Jin}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-018-22677-z",
language = "English",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Effects of Nonsteroidal Anti-Inflammatory Drugs as Patient Controlled Analgesia on Early Bowel Function Recovery after Radical Cystectomy. / Yu, Young Dong; Hwang, Jin Ho; Seo, Young Eun; Song, Byung Do; Jung, Yeon Soo; Lee, Dong Hwan; Hong, Sung Kyu; Byun, Seok-Soo; Lee, Sang Eun; Oh, Jong Jin.

In: Scientific Reports, Vol. 8, No. 1, 4658, 01.12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Nonsteroidal Anti-Inflammatory Drugs as Patient Controlled Analgesia on Early Bowel Function Recovery after Radical Cystectomy

AU - Yu, Young Dong

AU - Hwang, Jin Ho

AU - Seo, Young Eun

AU - Song, Byung Do

AU - Jung, Yeon Soo

AU - Lee, Dong Hwan

AU - Hong, Sung Kyu

AU - Byun, Seok-Soo

AU - Lee, Sang Eun

AU - Oh, Jong Jin

PY - 2018/12/1

Y1 - 2018/12/1

N2 - This study aimed to evaluate the effects of ketorolac, a commonly used non-steroidal anti-inflammatory drug (NSAID) as patient controlled intravenous infusion analgesia (PCIA) for the patients underwent radical cystectomy (RC) due to bladder cancer regarding post-operational indices of recovery. Total seventy patients who underwent radical cystectomy for the treatment of bladder cancer were included in the study. 35 patients received ketorolac as PCIA (NSAIDS group) and 35 patients had morphine infusion as PCIA (morphine group). Pain intensity, bowel function recovery and length of hospital stay were evaluated. Early postoperative complications were analyzed according to surgical types (robot RC vs. open RC). Demographics were similar between two groups. NSAIDS group showed a significant reduction in postoperative vomiting (p = 0.001), time to flatus (p = 0.028), time to first bowel movement (p = 0.001) and time to first clear liquid diet (p = 0.002) compared with morphine group. No statistically significant differences were observed between two groups regarding length of hospitalization, and postoperative complications. For 48 hours after RC, pain relief was slightly better in morphine group (p < 0.001). Both open RC and robot RC cases showed significantly better bowel function recovery with NSAIDS groups. Ketorolac as PCIA is relatively effective in pain management with better gastrointestinal recovery after RC.

AB - This study aimed to evaluate the effects of ketorolac, a commonly used non-steroidal anti-inflammatory drug (NSAID) as patient controlled intravenous infusion analgesia (PCIA) for the patients underwent radical cystectomy (RC) due to bladder cancer regarding post-operational indices of recovery. Total seventy patients who underwent radical cystectomy for the treatment of bladder cancer were included in the study. 35 patients received ketorolac as PCIA (NSAIDS group) and 35 patients had morphine infusion as PCIA (morphine group). Pain intensity, bowel function recovery and length of hospital stay were evaluated. Early postoperative complications were analyzed according to surgical types (robot RC vs. open RC). Demographics were similar between two groups. NSAIDS group showed a significant reduction in postoperative vomiting (p = 0.001), time to flatus (p = 0.028), time to first bowel movement (p = 0.001) and time to first clear liquid diet (p = 0.002) compared with morphine group. No statistically significant differences were observed between two groups regarding length of hospitalization, and postoperative complications. For 48 hours after RC, pain relief was slightly better in morphine group (p < 0.001). Both open RC and robot RC cases showed significantly better bowel function recovery with NSAIDS groups. Ketorolac as PCIA is relatively effective in pain management with better gastrointestinal recovery after RC.

UR - http://www.scopus.com/inward/record.url?scp=85044276742&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-22677-z

DO - 10.1038/s41598-018-22677-z

M3 - Article

C2 - 29545530

AN - SCOPUS:85044276742

VL - 8

JO - Scientific reports

JF - Scientific reports

SN - 2045-2322

IS - 1

M1 - 4658

ER -