Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy

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Abstract

BackgroundIn this double-blind, randomized, placebo-controlled study, we evaluated the effects of magnesium sulphate on neuromuscular blocking agent requirements and analgesia in children with cerebral palsy (CP).MethodsWe randomly divided 61 children with CP undergoing orthopaedic surgery into two groups. The magnesium group (Group M) received magnesium sulphate 50 mg kg -1 i.v. as a bolus and 15 mg kg-1 h-1 by continuous infusion during the operation. The control group (Group S) received the same amount of isotonic saline. Rocuronium was administered 0.6 mg kg -1 before intubation and 0.1 mg kg-1 additionally when train-of-four counts were 2 or more. I.V. fentanyl and ketorolac were used to control postoperative pain. Total infused analgesic volumes and pain scores were evaluated at postoperative 30 min, and at 6, 24, and 48 h.ResultsThe rocuronium requirement of Group M was significantly less than that of Group S [0.29 (0.12) vs 0.42 (0.16) mg kg-1 h-1, P<0.05]. Cumulative analgesic consumption in Group M was significantly less after operation at 24 and 48 h (P<0.05), and pain scores in Group M were lower than in Group S during the entire postoperative period (P<0.05). Serum magnesium concentrations in Group M were higher until 24 h after operation (P<0.05). The incidence of postoperative nausea and vomiting and rescue drug injections was similar in the two groups. No shivering or adverse effects related to hypermagnesaemia were encountered.ConclusionsI.V. magnesium sulphate reduces rocuronium requirements and postoperative analgesic consumption in children with CP.

Original languageEnglish
Pages (from-to)344-350
Number of pages7
JournalBritish Journal of Anaesthesia
Volume104
Issue number3
DOIs
StatePublished - Mar 2010

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Neuromuscular Blocking Agents
Magnesium Sulfate
Cerebral Palsy
Analgesia
Analgesics
Magnesium
Drug Repositioning
Ketorolac
Shivering
Pain
Postoperative Nausea and Vomiting
Fentanyl
Postoperative Pain
Postoperative Period
Intubation
Orthopedics
Placebos
Control Groups
Injections
Incidence

Keywords

  • Anaesthesia
  • Analgesia
  • Ions
  • Magnesium
  • Neuromuscular block
  • Paediatric
  • Postoperative
  • Rocuronium

Cite this

@article{78b07c47f7b4491da5ae436cf38e18f8,
title = "Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy",
abstract = "BackgroundIn this double-blind, randomized, placebo-controlled study, we evaluated the effects of magnesium sulphate on neuromuscular blocking agent requirements and analgesia in children with cerebral palsy (CP).MethodsWe randomly divided 61 children with CP undergoing orthopaedic surgery into two groups. The magnesium group (Group M) received magnesium sulphate 50 mg kg -1 i.v. as a bolus and 15 mg kg-1 h-1 by continuous infusion during the operation. The control group (Group S) received the same amount of isotonic saline. Rocuronium was administered 0.6 mg kg -1 before intubation and 0.1 mg kg-1 additionally when train-of-four counts were 2 or more. I.V. fentanyl and ketorolac were used to control postoperative pain. Total infused analgesic volumes and pain scores were evaluated at postoperative 30 min, and at 6, 24, and 48 h.ResultsThe rocuronium requirement of Group M was significantly less than that of Group S [0.29 (0.12) vs 0.42 (0.16) mg kg-1 h-1, P<0.05]. Cumulative analgesic consumption in Group M was significantly less after operation at 24 and 48 h (P<0.05), and pain scores in Group M were lower than in Group S during the entire postoperative period (P<0.05). Serum magnesium concentrations in Group M were higher until 24 h after operation (P<0.05). The incidence of postoperative nausea and vomiting and rescue drug injections was similar in the two groups. No shivering or adverse effects related to hypermagnesaemia were encountered.ConclusionsI.V. magnesium sulphate reduces rocuronium requirements and postoperative analgesic consumption in children with CP.",
keywords = "Anaesthesia, Analgesia, Ions, Magnesium, Neuromuscular block, Paediatric, Postoperative, Rocuronium",
author = "Na, {Hyo Seok} and Lee, {Ji Hyun} and Hwang, {Jin Young} and Ryu, {Jung Hee} and Han, {Sung Hee} and Jeon, {Young Tae} and Sanghwan Do",
year = "2010",
month = "3",
doi = "10.1093/bja/aep379",
language = "English",
volume = "104",
pages = "344--350",
journal = "British journal of anaesthesia",
issn = "0007-0912",
publisher = "Elsevier Ltd",
number = "3",

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TY - JOUR

T1 - Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy

AU - Na, Hyo Seok

AU - Lee, Ji Hyun

AU - Hwang, Jin Young

AU - Ryu, Jung Hee

AU - Han, Sung Hee

AU - Jeon, Young Tae

AU - Do, Sanghwan

PY - 2010/3

Y1 - 2010/3

N2 - BackgroundIn this double-blind, randomized, placebo-controlled study, we evaluated the effects of magnesium sulphate on neuromuscular blocking agent requirements and analgesia in children with cerebral palsy (CP).MethodsWe randomly divided 61 children with CP undergoing orthopaedic surgery into two groups. The magnesium group (Group M) received magnesium sulphate 50 mg kg -1 i.v. as a bolus and 15 mg kg-1 h-1 by continuous infusion during the operation. The control group (Group S) received the same amount of isotonic saline. Rocuronium was administered 0.6 mg kg -1 before intubation and 0.1 mg kg-1 additionally when train-of-four counts were 2 or more. I.V. fentanyl and ketorolac were used to control postoperative pain. Total infused analgesic volumes and pain scores were evaluated at postoperative 30 min, and at 6, 24, and 48 h.ResultsThe rocuronium requirement of Group M was significantly less than that of Group S [0.29 (0.12) vs 0.42 (0.16) mg kg-1 h-1, P<0.05]. Cumulative analgesic consumption in Group M was significantly less after operation at 24 and 48 h (P<0.05), and pain scores in Group M were lower than in Group S during the entire postoperative period (P<0.05). Serum magnesium concentrations in Group M were higher until 24 h after operation (P<0.05). The incidence of postoperative nausea and vomiting and rescue drug injections was similar in the two groups. No shivering or adverse effects related to hypermagnesaemia were encountered.ConclusionsI.V. magnesium sulphate reduces rocuronium requirements and postoperative analgesic consumption in children with CP.

AB - BackgroundIn this double-blind, randomized, placebo-controlled study, we evaluated the effects of magnesium sulphate on neuromuscular blocking agent requirements and analgesia in children with cerebral palsy (CP).MethodsWe randomly divided 61 children with CP undergoing orthopaedic surgery into two groups. The magnesium group (Group M) received magnesium sulphate 50 mg kg -1 i.v. as a bolus and 15 mg kg-1 h-1 by continuous infusion during the operation. The control group (Group S) received the same amount of isotonic saline. Rocuronium was administered 0.6 mg kg -1 before intubation and 0.1 mg kg-1 additionally when train-of-four counts were 2 or more. I.V. fentanyl and ketorolac were used to control postoperative pain. Total infused analgesic volumes and pain scores were evaluated at postoperative 30 min, and at 6, 24, and 48 h.ResultsThe rocuronium requirement of Group M was significantly less than that of Group S [0.29 (0.12) vs 0.42 (0.16) mg kg-1 h-1, P<0.05]. Cumulative analgesic consumption in Group M was significantly less after operation at 24 and 48 h (P<0.05), and pain scores in Group M were lower than in Group S during the entire postoperative period (P<0.05). Serum magnesium concentrations in Group M were higher until 24 h after operation (P<0.05). The incidence of postoperative nausea and vomiting and rescue drug injections was similar in the two groups. No shivering or adverse effects related to hypermagnesaemia were encountered.ConclusionsI.V. magnesium sulphate reduces rocuronium requirements and postoperative analgesic consumption in children with CP.

KW - Anaesthesia

KW - Analgesia

KW - Ions

KW - Magnesium

KW - Neuromuscular block

KW - Paediatric

KW - Postoperative

KW - Rocuronium

UR - http://www.scopus.com/inward/record.url?scp=77249094622&partnerID=8YFLogxK

U2 - 10.1093/bja/aep379

DO - 10.1093/bja/aep379

M3 - Article

C2 - 20042475

AN - SCOPUS:77249094622

VL - 104

SP - 344

EP - 350

JO - British journal of anaesthesia

JF - British journal of anaesthesia

SN - 0007-0912

IS - 3

ER -