Effects of magnesium sulphate on coagulation after laparoscopic colorectal cancer surgery, measured by rotational thromboelastometry (ROTEM®)

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Abstract

We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg-1 followed by a continuous infusion of 15 mg.kg-1.h-1), whereas the control group received the same volume of isotonic saline. Mean (SD) postoperative serum magnesium levels were 1.60 (0.13) mmol.l-1 in the magnesium group compared with 0.98 (0.06) mmol.l-1 in the control group (p < 0.001). All maximum clot firmness values of ROTEM analysis were significantly lower on the third postoperative day in the magnesium group compared with the control group (p < 0.05). We conclude that ROTEM analysis demonstrated that intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.

Original languageEnglish
Pages (from-to)1314-1321
Number of pages8
JournalAnaesthesia
Volume69
Issue number12
DOIs
StatePublished - 1 Dec 2014

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Thrombelastography
Magnesium Sulfate
Colorectal Surgery
Magnesium
Colorectal Neoplasms
Control Groups
Thrombophilia
Blood Coagulation
Intravenous Administration
Serum

Cite this

@article{a18a6c0e951c42fbb4c3e8b7e07f87a2,
title = "Effects of magnesium sulphate on coagulation after laparoscopic colorectal cancer surgery, measured by rotational thromboelastometry (ROTEM{\circledR})",
abstract = "We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg-1 followed by a continuous infusion of 15 mg.kg-1.h-1), whereas the control group received the same volume of isotonic saline. Mean (SD) postoperative serum magnesium levels were 1.60 (0.13) mmol.l-1 in the magnesium group compared with 0.98 (0.06) mmol.l-1 in the control group (p < 0.001). All maximum clot firmness values of ROTEM analysis were significantly lower on the third postoperative day in the magnesium group compared with the control group (p < 0.05). We conclude that ROTEM analysis demonstrated that intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.",
author = "Na, {Hyo Seok} and Shin, {Hyun Jeong} and Kang, {Sung Bum} and Jung-Won Hwang and Sanghwan Do",
year = "2014",
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TY - JOUR

T1 - Effects of magnesium sulphate on coagulation after laparoscopic colorectal cancer surgery, measured by rotational thromboelastometry (ROTEM®)

AU - Na, Hyo Seok

AU - Shin, Hyun Jeong

AU - Kang, Sung Bum

AU - Hwang, Jung-Won

AU - Do, Sanghwan

PY - 2014/12/1

Y1 - 2014/12/1

N2 - We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg-1 followed by a continuous infusion of 15 mg.kg-1.h-1), whereas the control group received the same volume of isotonic saline. Mean (SD) postoperative serum magnesium levels were 1.60 (0.13) mmol.l-1 in the magnesium group compared with 0.98 (0.06) mmol.l-1 in the control group (p < 0.001). All maximum clot firmness values of ROTEM analysis were significantly lower on the third postoperative day in the magnesium group compared with the control group (p < 0.05). We conclude that ROTEM analysis demonstrated that intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.

AB - We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg-1 followed by a continuous infusion of 15 mg.kg-1.h-1), whereas the control group received the same volume of isotonic saline. Mean (SD) postoperative serum magnesium levels were 1.60 (0.13) mmol.l-1 in the magnesium group compared with 0.98 (0.06) mmol.l-1 in the control group (p < 0.001). All maximum clot firmness values of ROTEM analysis were significantly lower on the third postoperative day in the magnesium group compared with the control group (p < 0.05). We conclude that ROTEM analysis demonstrated that intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.

UR - http://www.scopus.com/inward/record.url?scp=84922017173&partnerID=8YFLogxK

U2 - 10.1111/anae.12684

DO - 10.1111/anae.12684

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VL - 69

SP - 1314

EP - 1321

JO - Anaesthesia

JF - Anaesthesia

SN - 0003-2409

IS - 12

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