Effects of leucine-rich protein supplements in older adults with sarcopenia: A systematic review and meta-analysis of randomized controlled trials

Sang Yoon Lee, Hyun Jeong Lee, Jae Young Lim

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objectives: This study examined whether leucine-rich protein supplements improve muscle strength, mass, and performance in sarcopenic older adults. Methods: We searched PubMed-Medline, Embase, and Cochrane Library databases for randomized controlled trials comparing leucine-rich protein supplements with a control intervention in sarcopenic older adults. A pairwise meta-analysis using a fixed-effects model was performed. The primary outcome of interest was muscle strength regardless of the measures used. Effect sizes were computed as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Results: Six randomized controlled trials including a total of 699 participants were retrieved. Leucine-rich protein supplements improved participants’ overall muscle strength, mass, and performance compared to the control group (SMD = 0.939; 95% CI, 0.440–1.438; P < 0.001). As the primary outcome, muscle strength improved significantly in the leucine group (SMD = 0.794; 95% CI, 0.104–1.485; P = 0.024). Conclusion: Leucine-rich protein supplements improve muscle strength in sarcopenic older adults. They may be suggested in nutritional treatment of sarcopenia.

Original languageEnglish
Article number104758
JournalArchives of Gerontology and Geriatrics
Volume102
DOIs
StatePublished - 1 Sep 2022
Externally publishedYes

Keywords

  • Aging
  • Leucine
  • Meta-analysis
  • Nutritional support
  • Sarcopenia

Fingerprint

Dive into the research topics of 'Effects of leucine-rich protein supplements in older adults with sarcopenia: A systematic review and meta-analysis of randomized controlled trials'. Together they form a unique fingerprint.

Cite this