Effects of environmental cadmium exposure on liver function in adults

Mo Yeol Kang, Soo Hun Cho, Youn Hee Lim, Jeong Cheol Seo, Yun Chul Hong

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background There is inconsistency regarding the effects of cadmium exposure on liver function between the positive results found in animal studies and the negative results highlighted in epidemiological studies. We investigated whether environmental cadmium exposure is associated with an elevation in serum liver enzyme activity in Korean adults. Methods This cross-sectional study evaluated adult participants without liver disease from the Korean National Health and Nutrition Examination Survey for 2008-2009. Multiple linear regression was conducted to investigate the association between blood cadmium concentration and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) adjusting for age, sex, body mass index and the amount of alcohol consumption. Subjects were stratified into quartiles by their cumulative cadmium exposure rank. We estimated the multivariate-adjusted ORs for liver enzyme elevation using logistic regression models with the first quartile as the reference group. Results Total number of the subjects in the analysis was 3914. The blood cadmium concentrations were significantly associated with liver enzyme levels (AST, β=2.677, p value <0.0001; ALT, β=3.696, p value <0.0001; ALP, β=11.730, p value <0.0001). As the cadmium levels approached higher quartiles, the ORs for an elevated AST, ALT and ALP was increased significantly. Conclusions Environmental cadmium exposures are associated with an elevation in serum liver enzyme levels in Korean adults.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalOccupational and Environmental Medicine
Volume70
Issue number4
DOIs
StatePublished - 1 Apr 2013

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Environmental Exposure
Cadmium
Liver
Aspartate Aminotransferases
Alanine Transaminase
Alkaline Phosphatase
Enzymes
Logistic Models
Serum
Nutrition Surveys
Alcohol Drinking
Liver Diseases
Epidemiologic Studies
Linear Models
Body Mass Index
Cross-Sectional Studies

Cite this

Kang, Mo Yeol ; Cho, Soo Hun ; Lim, Youn Hee ; Seo, Jeong Cheol ; Hong, Yun Chul. / Effects of environmental cadmium exposure on liver function in adults. In: Occupational and Environmental Medicine. 2013 ; Vol. 70, No. 4. pp. 268-273.
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Effects of environmental cadmium exposure on liver function in adults. / Kang, Mo Yeol; Cho, Soo Hun; Lim, Youn Hee; Seo, Jeong Cheol; Hong, Yun Chul.

In: Occupational and Environmental Medicine, Vol. 70, No. 4, 01.04.2013, p. 268-273.

Research output: Contribution to journalArticle

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