Effects of antipsychotics on rumination in patients with first-episode psychosis

Youngmin Lee, Nam In Kang, Keon Hak Lee, Yan Hong Piao, Yin Cui, Sung Wan Kim, Bong Ju Lee, Jung Jin Kim, Je Chun Yu, Kyu Young Lee, Seung Hee Won, Seung Hwan Lee, Seung Hyun Kim, Shi Hyun Kang, Euitae Kim, Saebom Kim, Young Chul Chung

Research output: Contribution to journalArticlepeer-review


Background: Rumination is a well-known risk factor for depression. It is also associated with negative and positive symptoms and suicidality in patients suffering from psychosis. However, no studies have addressed the effect of antipsychotics on rumination. Methods: Using the Brooding Scale (BS), we investigated the effect of antipsychotics on rumination at the 6-month follow up in patients with first-episode psychosis (n = 257). The relationship between rumination and other clinical variables was explored by conducting a correlation analysis and structural equation modeling (SEM). The clinical characteristics and short-term outcomes were compared between high and low ruminators at 6 months. Results: Significant reductions in rumination and various clinical variables were observed at the 6-month follow-up. A significant correlation was observed between rumination and the score on the positive subscale of the Positive and Negative Syndrome Scale (PANSS). A direct path between the PANSS score and rumination was identified by SEM. High ruminators had more severe psychopathology, experienced more childhood traumas, and took less exercise than low ruminators. The recovery rate at 6 months was higher in low ruminators than in high ruminators. Conclusions: Our findings suggest that antipsychotics are beneficial for reducing rumination in patients with first-episode psychosis. The outcomes at the 6-month follow-up were better in low ruminators than high ruminators.

Original languageEnglish
Article number109983
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
StatePublished - 20 Dec 2020


  • Antipsychotics
  • First-episode psychosis
  • Full recovery
  • Rumination

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