Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels

Young Joon Hong, Myung Ho Jeong, Youngkeun Ahn, Sang Wook Kim, Jang Ho Bae, Seung Ho Hur, Tae Hoon Ahn, Seung Woon Rha, Kee Sik Kim, In Ho Chae, Jong Hyun Kim, Kyeong Ho Yun, Seok Kyu Oh

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9 Scopus citations

Abstract

Background: There are few data regarding the effect of statins on regression and compositional changes of plaque according to the reduction in high-sensitivity C-reactive protein (hs-CRP) levels in acute myocardial infarction (AMI) patients. Methods: We used serial virtual histology-intravascular ultrasound to assess the efficacy of pitavastatin (dosage: 2. mg/day) on plaque regression and compositional changes according to the degree of reduction in hs-CRP levels from baseline to follow-up [≥1. mg/dl (n= 62) vs. <1. mg/dl (n= 32)] in non-intervened non-infarct related artery in AMI patients who were enrolled in the Livalo in acute myocardial infarction study (LAMIS). Results: Total atheroma and percent atheroma volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-1.7±12.4mm3 vs. +2.7±7.8mm3, p<0.015, and -0.4±3.4% vs. +0.4±4.8%, p<0.001, respectively). Absolute and %necrotic core volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-0.4±3.5mm3 vs. +1.9±3.4mm3, p=0.038, and -1.1±4.9% vs. +2.7±4.7%, p=0.016, respectively). Reduction in hs-CRP ≥1mg/dl at follow-up was the independent predictor of reduction of percent atheroma volume and %necrotic core volume at follow-up [odds ratio (OR), 2.228; 95% confidence interval (CI), 1.390-2.977, p=0.016, and OR, 2.204; 95% CI, 1.512-2.916, p=0.020, respectively]. Conclusions: Reduction in hs-CRP levels in AMI patients plays an important role in the beneficial effects of statins on the regression and compositional change of coronary plaque.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalJournal of Cardiology
Volume60
Issue number4
DOIs
StatePublished - Oct 2012

Keywords

  • Acute myocardial infarction
  • Inflammation
  • Intravascular ultrasound
  • Plaque
  • Statin

Cite this

Hong, Y. J., Jeong, M. H., Ahn, Y., Kim, S. W., Bae, J. H., Hur, S. H., Ahn, T. H., Rha, S. W., Kim, K. S., Chae, I. H., Kim, J. H., Yun, K. H., & Oh, S. K. (2012). Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels. Journal of Cardiology, 60(4), 277-282. https://doi.org/10.1016/j.jjcc.2012.04.003