Effect of phlorofucofuroeckol a and dieckol extracted from ecklonia cava on noise-induced hearing loss in a mouse model

Hyunjun Woo, Min Kyung Kim, Sohyeon Park, Seung Hee Han, Hyeon Cheol Shin, Byeong Gon Kim, Seung Ha Oh, Myung Whan Suh, Jun Ho Lee, Moo Kyun Park

Research output: Contribution to journalArticlepeer-review


One of the well-known causes of hearing loss is noise. Approximately 31.1% of Americans between the ages of 20 and 69 years (61.1 million people) have high-frequency hearing loss associated with noise exposure. In addition, recurrent noise exposure can accelerate age-related hearing loss. Phlorofucofuroeckol A (PFF-A) and dieckol, polyphenols extracted from the brown alga Ecklonia cava, are potent antioxidant agents. In this study, we investigated the effect of PFF-A and dieckol on the consequences of noise exposure in mice. In 1,1-diphenyl-2-picrylhydrazyl assay, dieckol and PFF-A both showed significant radical-scavenging activity. The mice were exposed to 115 dB SPL of noise one single time for 2 h. Auditory brainstem response(ABR) threshold shifts 4 h after 4 kHz noise exposure in mice that received dieckol were significantly lower than those in the saline with noise group. The high-PFF-A group showed a lower threshold shift at click and 16 kHz 1 day after noise exposure than the control group. The high-PFF-A group also showed higher hair cell survival than in the control at 3 days after exposure in the apical turn. These results suggest that noise-induced hair cell damage in cochlear and the ABR threshold shift can be alleviated by dieckol and PFF-A in the mouse. Derivatives of these compounds may be applied to individuals who are inevitably exposed to noise, contributing to the prevention of noise-induced hearing loss with a low probability of adverse effects.

Original languageEnglish
Article number443
JournalMarine Drugs
Issue number8
StatePublished - Aug 2021
Externally publishedYes


  • Antioxidant
  • Dieckol
  • Hearing loss
  • Noise
  • PFF-A


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