Effect of Immunomodulators and Biologic Agents on Malignancy in Patients with Inflammatory Bowel Disease

Jee Hyun Kim, Ji Won Kim

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Immunosuppressive agents and biological agents are widely used for therapy in patients with inflammatory bowel disease (IBD). However, these therapies may be associated with an increased risk of malignancy. There is evidence that exposure of the therapeutic agents such as thiopurine and anti-tumor necrosis factor for IBD is associated with an increased risk of lymphoproliferative disorders, skin cancers, or uterine cervical cancers. This article reviews the malignancies associated with the use of immunosuppressive agents and biological agents in IBD.

Original languageEnglish
Pages (from-to)162-168
Number of pages7
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume70
Issue number4
DOIs
StatePublished - 25 Oct 2017

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Immunologic Factors
Biological Factors
Inflammatory Bowel Diseases
Immunosuppressive Agents
Neoplasms
Lymphoproliferative Disorders
Skin Neoplasms
Uterine Cervical Neoplasms
Therapeutics
Tumor Necrosis Factor-alpha

Keywords

  • 6-Mercaptopurine
  • Azathioprine
  • Inflammatory bowel disease
  • Malignancy
  • Tumor necrosis factor-alpha

Cite this

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abstract = "Immunosuppressive agents and biological agents are widely used for therapy in patients with inflammatory bowel disease (IBD). However, these therapies may be associated with an increased risk of malignancy. There is evidence that exposure of the therapeutic agents such as thiopurine and anti-tumor necrosis factor for IBD is associated with an increased risk of lymphoproliferative disorders, skin cancers, or uterine cervical cancers. This article reviews the malignancies associated with the use of immunosuppressive agents and biological agents in IBD.",
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Effect of Immunomodulators and Biologic Agents on Malignancy in Patients with Inflammatory Bowel Disease. / Kim, Jee Hyun; Kim, Ji Won.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 70, No. 4, 25.10.2017, p. 162-168.

Research output: Contribution to journalReview articleResearchpeer-review

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