Effect of airflow limitation on acute exacerbations in patients with destroyed lungs by tuberculosis

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Abstract

History of treatment for tuberculosis (TB) is a risk factor for obstructive lung disease. However, it has been unclear whether the clinical characteristics of patients with destroyed lung by TB differ according to the presence or absence of airflow limitation. The objective of the study was to evaluate differences in acute exacerbations and forced expiratory volume in 1 second (FEV1) decline in patients with destroyed lung by TB according to the presence or absence of airflow limitation. We performed a retrospective cohort study and enrolled patients with destroyed lung by TB. The presence of airflow limitation was defined as FEV1/forced vital capacity (FVC) < 0.7. One hundred and fifty-nine patients were enrolled, and 128 (80.5%) had airflow limitation. The proportion of patients who experienced acute exacerbation was higher in patients with airflow limitation compared to those without (89.1 vs. 67.7%, respectively; P = 0.009). The rate of acute exacerbation was higher in patients with airflow limitation (IRR, 1.19; 95% CI, 1.11-1.27). Low body mass index (X vs. X + 1; HR, 0.944; 95% CI, 0.895-0.996) in addition to airflow limitation (HR, 1.634; 95% CI, 1.012-2.638), was an independent risk factor for acute exacerbation. The annual decline of FEV1 was 2 mL in patients with airflow limitation and 36 mL in those without (P < 0.001). In conclusion, the presence of airflow limitation is an independent risk factor for acute exacerbation in patients with the destroyed lung by TB.

Original languageEnglish
Pages (from-to)737-742
Number of pages6
JournalJournal of Korean Medical Science
Volume30
Issue number6
DOIs
StatePublished - 1 Jan 2015

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Tuberculosis
Lung
Forced Expiratory Volume
Obstructive Lung Diseases
Vital Capacity
Body Mass Index
Cohort Studies
Retrospective Studies

Keywords

  • Acute exacerbation
  • Airflow limitation
  • Pulmonary function
  • Tuberculosis

Cite this

@article{07937c1e06e24702aa32a5935e7f91af,
title = "Effect of airflow limitation on acute exacerbations in patients with destroyed lungs by tuberculosis",
abstract = "History of treatment for tuberculosis (TB) is a risk factor for obstructive lung disease. However, it has been unclear whether the clinical characteristics of patients with destroyed lung by TB differ according to the presence or absence of airflow limitation. The objective of the study was to evaluate differences in acute exacerbations and forced expiratory volume in 1 second (FEV1) decline in patients with destroyed lung by TB according to the presence or absence of airflow limitation. We performed a retrospective cohort study and enrolled patients with destroyed lung by TB. The presence of airflow limitation was defined as FEV1/forced vital capacity (FVC) < 0.7. One hundred and fifty-nine patients were enrolled, and 128 (80.5{\%}) had airflow limitation. The proportion of patients who experienced acute exacerbation was higher in patients with airflow limitation compared to those without (89.1 vs. 67.7{\%}, respectively; P = 0.009). The rate of acute exacerbation was higher in patients with airflow limitation (IRR, 1.19; 95{\%} CI, 1.11-1.27). Low body mass index (X vs. X + 1; HR, 0.944; 95{\%} CI, 0.895-0.996) in addition to airflow limitation (HR, 1.634; 95{\%} CI, 1.012-2.638), was an independent risk factor for acute exacerbation. The annual decline of FEV1 was 2 mL in patients with airflow limitation and 36 mL in those without (P < 0.001). In conclusion, the presence of airflow limitation is an independent risk factor for acute exacerbation in patients with the destroyed lung by TB.",
keywords = "Acute exacerbation, Airflow limitation, Pulmonary function, Tuberculosis",
author = "Kim, {Soo Jung} and Jinwoo Lee and Park, {Young Sik} and Lee, {Chang Hoon} and Lee, {Sang Min} and Yim, {Jae Joon} and Kim, {Young Whan} and Han, {Sung Koo} and Yoo, {Chul Gyu}",
year = "2015",
month = "1",
day = "1",
doi = "10.3346/jkms.2015.30.6.737",
language = "English",
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pages = "737--742",
journal = "Journal of Korean medical science",
issn = "1011-8934",
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TY - JOUR

T1 - Effect of airflow limitation on acute exacerbations in patients with destroyed lungs by tuberculosis

AU - Kim, Soo Jung

AU - Lee, Jinwoo

AU - Park, Young Sik

AU - Lee, Chang Hoon

AU - Lee, Sang Min

AU - Yim, Jae Joon

AU - Kim, Young Whan

AU - Han, Sung Koo

AU - Yoo, Chul Gyu

PY - 2015/1/1

Y1 - 2015/1/1

N2 - History of treatment for tuberculosis (TB) is a risk factor for obstructive lung disease. However, it has been unclear whether the clinical characteristics of patients with destroyed lung by TB differ according to the presence or absence of airflow limitation. The objective of the study was to evaluate differences in acute exacerbations and forced expiratory volume in 1 second (FEV1) decline in patients with destroyed lung by TB according to the presence or absence of airflow limitation. We performed a retrospective cohort study and enrolled patients with destroyed lung by TB. The presence of airflow limitation was defined as FEV1/forced vital capacity (FVC) < 0.7. One hundred and fifty-nine patients were enrolled, and 128 (80.5%) had airflow limitation. The proportion of patients who experienced acute exacerbation was higher in patients with airflow limitation compared to those without (89.1 vs. 67.7%, respectively; P = 0.009). The rate of acute exacerbation was higher in patients with airflow limitation (IRR, 1.19; 95% CI, 1.11-1.27). Low body mass index (X vs. X + 1; HR, 0.944; 95% CI, 0.895-0.996) in addition to airflow limitation (HR, 1.634; 95% CI, 1.012-2.638), was an independent risk factor for acute exacerbation. The annual decline of FEV1 was 2 mL in patients with airflow limitation and 36 mL in those without (P < 0.001). In conclusion, the presence of airflow limitation is an independent risk factor for acute exacerbation in patients with the destroyed lung by TB.

AB - History of treatment for tuberculosis (TB) is a risk factor for obstructive lung disease. However, it has been unclear whether the clinical characteristics of patients with destroyed lung by TB differ according to the presence or absence of airflow limitation. The objective of the study was to evaluate differences in acute exacerbations and forced expiratory volume in 1 second (FEV1) decline in patients with destroyed lung by TB according to the presence or absence of airflow limitation. We performed a retrospective cohort study and enrolled patients with destroyed lung by TB. The presence of airflow limitation was defined as FEV1/forced vital capacity (FVC) < 0.7. One hundred and fifty-nine patients were enrolled, and 128 (80.5%) had airflow limitation. The proportion of patients who experienced acute exacerbation was higher in patients with airflow limitation compared to those without (89.1 vs. 67.7%, respectively; P = 0.009). The rate of acute exacerbation was higher in patients with airflow limitation (IRR, 1.19; 95% CI, 1.11-1.27). Low body mass index (X vs. X + 1; HR, 0.944; 95% CI, 0.895-0.996) in addition to airflow limitation (HR, 1.634; 95% CI, 1.012-2.638), was an independent risk factor for acute exacerbation. The annual decline of FEV1 was 2 mL in patients with airflow limitation and 36 mL in those without (P < 0.001). In conclusion, the presence of airflow limitation is an independent risk factor for acute exacerbation in patients with the destroyed lung by TB.

KW - Acute exacerbation

KW - Airflow limitation

KW - Pulmonary function

KW - Tuberculosis

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U2 - 10.3346/jkms.2015.30.6.737

DO - 10.3346/jkms.2015.30.6.737

M3 - Article

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EP - 742

JO - Journal of Korean medical science

JF - Journal of Korean medical science

SN - 1011-8934

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ER -