Early detection of acral melanoma

A review of clinical, dermoscopic, histopathologic, and molecular characteristics

Claudia C. Darmawan, Gwanghyun Jo, Sara E. Montenegro, Yoonjin Kwak, Lee Cheol, Kwang Hyun Cho, Je-Ho Mun

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Acral lentiginous melanoma is a distinct subtype of melanoma on acral skin. Patient presentation at later stages and delayed diagnosis by physicians contribute to a worse associated prognosis and survival rate. Despite our progress in understanding the key features of this disease, the diagnosis of early-stage acral melanoma is still challenging. It is essential to integrate clinical, dermoscopic, and histologic findings in the diagnosis of acral lentiginous melanoma. In addition, molecular studies can be helpful. In this review, we have summarized our current understanding of this disease entity from articles that were published between 1969 and 2018. We have outlined clinical and dermoscopic features as well as pathologic and molecular findings regarding acral melanoma and have presented an algorithm for diagnosis. Understanding and integrating these characteristics may assist clinicians in the early detection of acral melanomas.

Original languageEnglish
Pages (from-to)805-812
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume81
Issue number3
DOIs
StatePublished - 1 Sep 2019

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Melanoma
Extremities
Delayed Diagnosis
Survival Rate
Physicians
Skin

Keywords

  • acral melanoma
  • algorithm
  • dermoscopy
  • diagnosis
  • foot
  • genetics
  • histopathology
  • melanoma
  • molecular
  • review

Cite this

Darmawan, Claudia C. ; Jo, Gwanghyun ; Montenegro, Sara E. ; Kwak, Yoonjin ; Cheol, Lee ; Cho, Kwang Hyun ; Mun, Je-Ho. / Early detection of acral melanoma : A review of clinical, dermoscopic, histopathologic, and molecular characteristics. In: Journal of the American Academy of Dermatology. 2019 ; Vol. 81, No. 3. pp. 805-812.
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abstract = "Acral lentiginous melanoma is a distinct subtype of melanoma on acral skin. Patient presentation at later stages and delayed diagnosis by physicians contribute to a worse associated prognosis and survival rate. Despite our progress in understanding the key features of this disease, the diagnosis of early-stage acral melanoma is still challenging. It is essential to integrate clinical, dermoscopic, and histologic findings in the diagnosis of acral lentiginous melanoma. In addition, molecular studies can be helpful. In this review, we have summarized our current understanding of this disease entity from articles that were published between 1969 and 2018. We have outlined clinical and dermoscopic features as well as pathologic and molecular findings regarding acral melanoma and have presented an algorithm for diagnosis. Understanding and integrating these characteristics may assist clinicians in the early detection of acral melanomas.",
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Early detection of acral melanoma : A review of clinical, dermoscopic, histopathologic, and molecular characteristics. / Darmawan, Claudia C.; Jo, Gwanghyun; Montenegro, Sara E.; Kwak, Yoonjin; Cheol, Lee; Cho, Kwang Hyun; Mun, Je-Ho.

In: Journal of the American Academy of Dermatology, Vol. 81, No. 3, 01.09.2019, p. 805-812.

Research output: Contribution to journalReview articleResearchpeer-review

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