Dynamics of gut microbiota according to the delivery mode in healthy Korean infants

Eun Lee, Byoung Ju Kim, Mi Jin Kang, Kil Yong Choi, Hyun Ju Cho, Yeongho Kim, Song I. Yang, Young Ho Jung, Hyung Young Kim, Ju Hee Seo, Ji Won Kwon, Hyo Bin Kim, So Yeon Lee, Soo Jong Hong

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Microbial colonization of the infant gut is unstable and shows a wide range of diversity between individuals. Gut microbiota play an important role in the development of the immune system, and an imbalance in these organisms can affect health, including an increased risk of allergic diseases. Microbial colonization of young infants is affected by the delivery mode at birth and the consequent alterations of gut microbiota in early life affect the development of allergic diseases. We investigated the effects of the delivery mode on the temporal dynamics of gut microbiota in healthy Korean infants. Fecal samples were collected at 1-3 days, 1 month, and 6 months after birth in six healthy infants. Microbiota were characterized by 16S rRNA shotgun sequencing. At the first and third days of life, infants born by vaginal delivery showed a higher richness and diversity of gut microbiota compared with those born by cesarean section. However, these differences disappeared with age. The Bacteroides genus and Bacteroidetes phylum were abundant in infants born by vaginal delivery, whereas Bacilli and Clostridium g4 were increased in infants born by cesarean section. The Firmicutes phylum and Bacteroides genus showed convergent dynamics with age. This study demonstrated the effect of delivery mode on the dynamics of gut microbiota profiles in healthy Korean infants.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalAllergy, Asthma and Immunology Research
Volume8
Issue number5
DOIs
StatePublished - 1 Jan 2016

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Bacteroides
Cesarean Section
Parturition
Bacteroidetes
Clostridium
Gastrointestinal Microbiome
Microbiota
Firearms
Bacillus
Immune System
Health
Firmicutes

Keywords

  • Delivery mode
  • Gut
  • Microbiota

Cite this

Lee, E., Kim, B. J., Kang, M. J., Choi, K. Y., Cho, H. J., Kim, Y., ... Hong, S. J. (2016). Dynamics of gut microbiota according to the delivery mode in healthy Korean infants. Allergy, Asthma and Immunology Research, 8(5), 471-477. https://doi.org/10.4168/aair.2016.8.5.471
Lee, Eun ; Kim, Byoung Ju ; Kang, Mi Jin ; Choi, Kil Yong ; Cho, Hyun Ju ; Kim, Yeongho ; Yang, Song I. ; Jung, Young Ho ; Kim, Hyung Young ; Seo, Ju Hee ; Kwon, Ji Won ; Kim, Hyo Bin ; Lee, So Yeon ; Hong, Soo Jong. / Dynamics of gut microbiota according to the delivery mode in healthy Korean infants. In: Allergy, Asthma and Immunology Research. 2016 ; Vol. 8, No. 5. pp. 471-477.
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Lee, E, Kim, BJ, Kang, MJ, Choi, KY, Cho, HJ, Kim, Y, Yang, SI, Jung, YH, Kim, HY, Seo, JH, Kwon, JW, Kim, HB, Lee, SY & Hong, SJ 2016, 'Dynamics of gut microbiota according to the delivery mode in healthy Korean infants', Allergy, Asthma and Immunology Research, vol. 8, no. 5, pp. 471-477. https://doi.org/10.4168/aair.2016.8.5.471

Dynamics of gut microbiota according to the delivery mode in healthy Korean infants. / Lee, Eun; Kim, Byoung Ju; Kang, Mi Jin; Choi, Kil Yong; Cho, Hyun Ju; Kim, Yeongho; Yang, Song I.; Jung, Young Ho; Kim, Hyung Young; Seo, Ju Hee; Kwon, Ji Won; Kim, Hyo Bin; Lee, So Yeon; Hong, Soo Jong.

In: Allergy, Asthma and Immunology Research, Vol. 8, No. 5, 01.01.2016, p. 471-477.

Research output: Contribution to journalArticle

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AU - Yang, Song I.

AU - Jung, Young Ho

AU - Kim, Hyung Young

AU - Seo, Ju Hee

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AU - Lee, So Yeon

AU - Hong, Soo Jong

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