Dynamic change of neutrophil-to-lymphocyte ratio and symptomatic intracerebral hemorrhage after endovascular recanalization therapy

Tae Jung Kim, Soo Hyun Park, Sang Bae Ko

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a known marker of systemic inflammation. Recent studies demonstrated its applicability as a marker of poor prognosis for stroke patients. In this study, we evaluated the relationship between dynamic changes in the NLR and sICH in patients with successful recanalization following ERT. Materials and methods: This study included 128 patients with acute ischemic stroke who underwent successful ERT between January 2013 and November 2019. We evaluated the NLR pre-ERT (at admission) and post-ERT (at 24–36 h after ERT). The symptomatic ICH and miserable outcomes at 3 months after ERT were analyzed as outcomes. sICH was defined as type-2 parenchymal hematoma with neurological deterioration (defined as National Institute of Health Stroke Scale score ≥4). Moreover, a modified Rankin Scale score of 5–6 at 3 months was considered a miserable outcome. Results: Among the included patients, sICH occurred in 12 (9.4%). The sICH group had significantly higher post-ERT NLR (P < 0.001) and ∆NLR (calculated as the difference between pre-ERT NLR and post-ERT NLR) (P = 0.004). In the multivariate analysis, the post-ERT NLR was independently associated with sICH (odds ratio [OR], 1.166; 95% confidence interval [CI], 1.041–1.306; P = 0.008) and miserable outcome at 3 months (OR, 1.101; 95% CI, 1.002–1.210; P = 0.045). Conclusions: This study demonstrated that temporal elevation of the NLR is associated with sICH events after successful ERT in patients with acute ischemic stroke. The temporal variation in NLR may help to identify high-risk patients with sICH after ERT.

Original languageEnglish
Article number106604
JournalJournal of Stroke and Cerebrovascular Diseases
Volume31
Issue number9
DOIs
StatePublished - Sep 2022

Keywords

  • Dynamic changes
  • Endovascular recanalization therapy
  • Hemorrhagic transformation
  • Neutrophil-to-lymphocyte ratio
  • Outcomes

Fingerprint

Dive into the research topics of 'Dynamic change of neutrophil-to-lymphocyte ratio and symptomatic intracerebral hemorrhage after endovascular recanalization therapy'. Together they form a unique fingerprint.

Cite this