Dnajb9 inhibits p53-dependent oncogene-induced senescence and induces cell transformation

Hyeon Ju Lee, Yu Jin Jung, Seungkoo Lee, Jong Il Kim, Jeong A. Han

Research output: Contribution to journalArticle

Abstract

DNAJB9 i s known to be a member of the mol ecul ar chaperone gene family, whose cellular function has not yet been fully characterized. Here, we investigated the cellular function of DNAJB9 under strong mitogenic signals. We found that DNAJB9 inhibits p53-dependent oncogene-induced senescence (OIS) and induces neoplastic transformation under oncogenic RAS activation in mouse primary fibroblasts. In addition, we observed that DNAJB9 interacts physically with p53 under oncogenic RAS activation and that the p53-interacting region of DNAJB9 is critical for the inhibition of p53-dependent OIS and induction of neoplastic transformation by DNAJB9. These results suggest that DNAJB9 induces cell transformation under strong mitogenic signals, which is attributable to the inhibition of p53-dependent OIS by physical interactions with p53. This study might contribute to our understanding of the cellular function of DNAJB9 and the molecular basis of cell transformation.

Original languageEnglish
Pages (from-to)397-407
Number of pages11
JournalMolecules and Cells
Volume43
Issue number4
DOIs
StatePublished - 30 Apr 2020

Keywords

  • DNAJB9
  • P53
  • RAS
  • Senescence
  • Transformation

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