Distance-dependent scaling of AMPARs is cell-autonomous and GluA2 dependent

Seth L. Shipman, Bruce E. Herring, Young Ho Suh, Katherine W. Roche, Roger A. Nicoll

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14 Citations (Scopus)

Abstract

The extensive dendritic arbor of a pyramidal cell introduces considerable complexity to the integration of synaptic potentials. Propagation of dendritic potentials is largely passive, in contrast to regenerative axonal potentials that are maintained by voltage-gated sodium channels, leading to a declination in amplitude as dendritic potentials travel toward the soma in a manner that disproportionally affects distal synaptic inputs. To counteract this amplitude filtering, Schaffer collateral synapses onto CA1 pyramidal cells contain a varying number of AMPA receptors (AMPARs) per synapse that increases with distance from the soma, a phenomenon known as distance-dependent scaling. Here, we undertake an investigation into the molecular mechanisms of distance-dependent scaling. Using dendritic recordings from rat pyramidal neurons, we confirm the basic scaling phenomenon and find that it is expressed and can be manipulated cell autonomously. Finally, we show that it depends on the presence of both a reserve pool of AMPARs and the AMPAR subunit GluA2.

Original languageEnglish
Pages (from-to)13312-13319
Number of pages8
JournalJournal of Neuroscience
Volume33
Issue number33
DOIs
StatePublished - 20 Aug 2013

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AMPA Receptors
Pyramidal Cells
Carisoprodol
Synapses
Voltage-Gated Sodium Channels
Synaptic Potentials
Hippocampus

Cite this

Shipman, Seth L. ; Herring, Bruce E. ; Suh, Young Ho ; Roche, Katherine W. ; Nicoll, Roger A. / Distance-dependent scaling of AMPARs is cell-autonomous and GluA2 dependent. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 33. pp. 13312-13319.
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Distance-dependent scaling of AMPARs is cell-autonomous and GluA2 dependent. / Shipman, Seth L.; Herring, Bruce E.; Suh, Young Ho; Roche, Katherine W.; Nicoll, Roger A.

In: Journal of Neuroscience, Vol. 33, No. 33, 20.08.2013, p. 13312-13319.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Herring, Bruce E.

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