Difficult diagnosis and localization of focal nesidioblastosis: Clinical implications of 68Gallium-DOTAD-Phe1-Tyr3-octreotide PET scanning

Jae Ri Kim, Jin Young Jang, Yong Chan Shin, Young Min Cho, Hongbeom Kim, Wooil Kwon, Young Min Han, Sun Whe Kim

Research output: Contribution to journalArticle

Abstract

Focal nesidioblastosis is a rare cause of endogenous hyperinsulinemic hypoglycemia in adults. Because it is difficult to localize and detect with current imaging modalities, nesidioblastosis is challenging for biliary-pancreatic surgeons. 68Gallium-DOTA-D-Phe1-Tyr3-octreotide PET scanning and 111indium-pentetreotide diethylene triamine pentaacetic acid octreotide scanning may be superior to conventional imaging modalities in determining the localization of nesidioblastosis. We report the successful surgical treatment of a 54-year-old woman with focal hyperplasia of the islets of Langerhans, who experienced frequent hypoglycemic symptoms and underwent various diagnostic examinations with different results.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalAnnals of Surgical Treatment and Research
Volume91
Issue number1
DOIs
StatePublished - Jul 2016

Keywords

  • Ga(III)-DOTATOC
  • Nesidioblastosis
  • Positron-emission tomography

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