Differential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbits

Sun Park Kyung, Ae Lee Hyang, Hyun Earm Kee, Hong Ko Jae, Yung E. Earm, Sungjoon Kim

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

The mechanosensitive nonselective cation channel (NSCMS) is a key player in vascular myogenic contraction. The functional channel density and pressure sensitivity of NSCMS in vascular myocytes were compared between pulmonary and systemic arteries (coronary, mesenteric and cerebral arteries) in the rabbit. In cell-attached condition, a negative pressure via patch pipettes commonly activated NSCMS with weak voltage dependence. The threshold pressure for activation was lower, and the density of NSCMS was higher in the pulmonary than the systemic arteries. When the pulmonary arteries were divided into small-diameter (outer diameter, OD < 0.5 mm) and large-diameter (OD > 1.5 mm) arteries, the low threshold and high density of NSCMS were observed only in small-diameter ones. No such difference was observed between the small- and large-diameter coronary arteries. The higher stretch sensitivity and denser functional expression of NSCMS in small pulmonary arteries might suggest an adaptive tuning for the relatively low pulmonary blood pressure in vivo.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalJournal of Vascular Research
Volume43
Issue number4
DOIs
StatePublished - 1 Jul 2006

Fingerprint

Muscle Cells
Pulmonary Artery
Cations
Rabbits
Lung
Pressure
Blood Vessels
Coronary Vessels
Mesenteric Arteries
Cerebral Arteries
Hypotension
Arteries

Keywords

  • Coronary artery
  • Membrane stretch
  • Nonselective cation channels
  • Patch clamp
  • Pulmonary artery
  • Rabbit
  • Smooth muscle

Cite this

Kyung, Sun Park ; Hyang, Ae Lee ; Kee, Hyun Earm ; Jae, Hong Ko ; Earm, Yung E. ; Kim, Sungjoon. / Differential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbits. In: Journal of Vascular Research. 2006 ; Vol. 43, No. 4. pp. 347-354.
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Differential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbits. / Kyung, Sun Park; Hyang, Ae Lee; Kee, Hyun Earm; Jae, Hong Ko; Earm, Yung E.; Kim, Sungjoon.

In: Journal of Vascular Research, Vol. 43, No. 4, 01.07.2006, p. 347-354.

Research output: Contribution to journalArticleResearchpeer-review

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