Different characteristics of ventilator application between tracheostomy- and noninvasive positive pressure ventilation patients with amyotrophic lateral sclerosis

Donghwi Park, Goo Joo Lee, Ha Young Kim, Ju Seok Ryu

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The aim of the study was to investigate the appropriate home ventilator settings for patients with amyotrophic lateral sclerosis (ALS). In total, 71 patients with ALS, who had received either a noninvasive positive pressure ventilation (NIPPV) or tracheostomy positive pressure ventilation (TPPV), were included. Accordingly, patients were divided into 2 groups (the TPPV and NIPPV groups). We retrospectively evaluated the values used in home ventilators for patients with ALS, who had maintained a stable level of CO 2 on both the arterial blood gas analysis (ABGA) and transcutaneous blood gas monitoring. To measure the main outcome, we also investigated the actual body weight (ABW) and predicted body weight (PBW) of patients, and the following setting values of ventilators were also recorded: the inspired tidal volume (V Ti), minute ventilation (MV), peak inspiratory pressure (PIP), positive end expiratory pressure (PEEP), and inspiratory time (T ins). V Ti and MV showed a significantly positive correlation with both PBW and ABW of patients in the TPPV group. However, both V Ti and MV had greater significant correlation with PBW than ABW in the TPPV group. In addition, V Ti and MV did not show a significantly positive correlation with either PBW or ABW in the NIPPV group. In patients with ALS, PBW was more useful for predicting V Ti and MV than ABW. Moreover, it will be helpful to know the differences of setting values between TPPV and NIPPV, especially because ALS patients are usually treated with TPPV due to the initial difficulties associated with NIPPV.

Original languageEnglish
Article numbere6251
JournalMedicine (United States)
Issue number10
StatePublished - 1 Mar 2017


  • amyotrophic lateral sclerosis
  • minute ventilation
  • tidal volume
  • ventilation

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