Differences in prognostic relevance of rectal magnetic resonance imaging findings before and after neoadjuvant chemoradiotherapy

Kwang Seop Song, Dong Woon Lee, Bun Kim, Bo Yun Hur, Min Jung Kim, Min Ju Kim, Chang Won Hong, Sung Chan Park, Hyoung Chul Park, Dae Kyung Sohn, Byung Chang Kim, Kyung Su Han, Jae Hwan Oh

Research output: Contribution to journalArticle

Abstract

This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings were examined. Factors examined included tumour (T), lymph node (N), mesorectal fascia (MRF), extramural venous invasion (EMVI), and tumour regression grade (TRG). Two Cox proportional hazard models were created using mr and ymr findings separately for overall survival (OS), disease-free survival (DFS), and local recurrence rate (LRR). Among mr findings, only mrEMVI was a significant prognostic factor for OS and DFS. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were significant prognostic factors for OS and DFS, whereas ymrMRF and ymrEMVI were significant prognostic factors for LRR. C-indices tended to be higher for ymr findings than for mr findings (OS, 0.682 vs. 0.635; DFS, 0.660 vs. 0.631; LRR, 0.701 vs. 0.617). Survival outcomes of patients having all ymr risk factors were significantly poor (5-year OS, 52.4%; 5-year DFS, 38.1%; 5-year LRR, 27.7%). ymr findings showed better prognostic significance than mr findings. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were independent prognostic factors for oncologic outcomes.

Original languageEnglish
Article number10059
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2019

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Chemoradiotherapy
Disease-Free Survival
Magnetic Resonance Imaging
Survival
Recurrence
Fascia
Rectal Neoplasms
Proportional Hazards Models
Neoplasms
Retrospective Studies
Lymph Nodes

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Song, Kwang Seop ; Lee, Dong Woon ; Kim, Bun ; Hur, Bo Yun ; Kim, Min Jung ; Kim, Min Ju ; Hong, Chang Won ; Park, Sung Chan ; Park, Hyoung Chul ; Sohn, Dae Kyung ; Kim, Byung Chang ; Han, Kyung Su ; Oh, Jae Hwan. / Differences in prognostic relevance of rectal magnetic resonance imaging findings before and after neoadjuvant chemoradiotherapy. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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title = "Differences in prognostic relevance of rectal magnetic resonance imaging findings before and after neoadjuvant chemoradiotherapy",
abstract = "This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings were examined. Factors examined included tumour (T), lymph node (N), mesorectal fascia (MRF), extramural venous invasion (EMVI), and tumour regression grade (TRG). Two Cox proportional hazard models were created using mr and ymr findings separately for overall survival (OS), disease-free survival (DFS), and local recurrence rate (LRR). Among mr findings, only mrEMVI was a significant prognostic factor for OS and DFS. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were significant prognostic factors for OS and DFS, whereas ymrMRF and ymrEMVI were significant prognostic factors for LRR. C-indices tended to be higher for ymr findings than for mr findings (OS, 0.682 vs. 0.635; DFS, 0.660 vs. 0.631; LRR, 0.701 vs. 0.617). Survival outcomes of patients having all ymr risk factors were significantly poor (5-year OS, 52.4{\%}; 5-year DFS, 38.1{\%}; 5-year LRR, 27.7{\%}). ymr findings showed better prognostic significance than mr findings. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were independent prognostic factors for oncologic outcomes.",
author = "Song, {Kwang Seop} and Lee, {Dong Woon} and Bun Kim and Hur, {Bo Yun} and Kim, {Min Jung} and Kim, {Min Ju} and Hong, {Chang Won} and Park, {Sung Chan} and Park, {Hyoung Chul} and Sohn, {Dae Kyung} and Kim, {Byung Chang} and Han, {Kyung Su} and Oh, {Jae Hwan}",
year = "2019",
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Song, KS, Lee, DW, Kim, B, Hur, BY, Kim, MJ, Kim, MJ, Hong, CW, Park, SC, Park, HC, Sohn, DK, Kim, BC, Han, KS & Oh, JH 2019, 'Differences in prognostic relevance of rectal magnetic resonance imaging findings before and after neoadjuvant chemoradiotherapy', Scientific Reports, vol. 9, no. 1, 10059. https://doi.org/10.1038/s41598-019-46499-9

Differences in prognostic relevance of rectal magnetic resonance imaging findings before and after neoadjuvant chemoradiotherapy. / Song, Kwang Seop; Lee, Dong Woon; Kim, Bun; Hur, Bo Yun; Kim, Min Jung; Kim, Min Ju; Hong, Chang Won; Park, Sung Chan; Park, Hyoung Chul; Sohn, Dae Kyung; Kim, Byung Chang; Han, Kyung Su; Oh, Jae Hwan.

In: Scientific Reports, Vol. 9, No. 1, 10059, 01.12.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differences in prognostic relevance of rectal magnetic resonance imaging findings before and after neoadjuvant chemoradiotherapy

AU - Song, Kwang Seop

AU - Lee, Dong Woon

AU - Kim, Bun

AU - Hur, Bo Yun

AU - Kim, Min Jung

AU - Kim, Min Ju

AU - Hong, Chang Won

AU - Park, Sung Chan

AU - Park, Hyoung Chul

AU - Sohn, Dae Kyung

AU - Kim, Byung Chang

AU - Han, Kyung Su

AU - Oh, Jae Hwan

PY - 2019/12/1

Y1 - 2019/12/1

N2 - This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings were examined. Factors examined included tumour (T), lymph node (N), mesorectal fascia (MRF), extramural venous invasion (EMVI), and tumour regression grade (TRG). Two Cox proportional hazard models were created using mr and ymr findings separately for overall survival (OS), disease-free survival (DFS), and local recurrence rate (LRR). Among mr findings, only mrEMVI was a significant prognostic factor for OS and DFS. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were significant prognostic factors for OS and DFS, whereas ymrMRF and ymrEMVI were significant prognostic factors for LRR. C-indices tended to be higher for ymr findings than for mr findings (OS, 0.682 vs. 0.635; DFS, 0.660 vs. 0.631; LRR, 0.701 vs. 0.617). Survival outcomes of patients having all ymr risk factors were significantly poor (5-year OS, 52.4%; 5-year DFS, 38.1%; 5-year LRR, 27.7%). ymr findings showed better prognostic significance than mr findings. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were independent prognostic factors for oncologic outcomes.

AB - This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings were examined. Factors examined included tumour (T), lymph node (N), mesorectal fascia (MRF), extramural venous invasion (EMVI), and tumour regression grade (TRG). Two Cox proportional hazard models were created using mr and ymr findings separately for overall survival (OS), disease-free survival (DFS), and local recurrence rate (LRR). Among mr findings, only mrEMVI was a significant prognostic factor for OS and DFS. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were significant prognostic factors for OS and DFS, whereas ymrMRF and ymrEMVI were significant prognostic factors for LRR. C-indices tended to be higher for ymr findings than for mr findings (OS, 0.682 vs. 0.635; DFS, 0.660 vs. 0.631; LRR, 0.701 vs. 0.617). Survival outcomes of patients having all ymr risk factors were significantly poor (5-year OS, 52.4%; 5-year DFS, 38.1%; 5-year LRR, 27.7%). ymr findings showed better prognostic significance than mr findings. Among ymr findings, ymrN, ymrMRF, and ymrEMVI were independent prognostic factors for oncologic outcomes.

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