Differences in mitochondrial DNA copy number between patients with bipolar I and II disorders

Jae Kyung Chung, Yong Min Ahn, Soon Ae Kim, Eun Jeong Joo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Mitochondria play a critical role in energy metabolism. Genetic, postmortem brain, and brain imaging studies of bipolar disorder (BD) patients indicated that mitochondrial dysfunction might explain BD pathophysiology. Mitochondrial function can be indirectly evaluated by measuring mitochondrial DNA (mtDNA) copy numbers. We recruited 186 bipolar I disorder (BD1) and 95 bipolar II disorder (BD2) patients, and age- and sex-matched controls. MtDNA copy numbers in peripheral blood cells were measured via quantitative polymerase chain reaction. We explored parameters (including age and clinical features) that might affect mtDNA copy numbers. We found that BD1 patients had a lower mtDNA copy number than controls and that mtDNA copy number was negatively associated with the number of mood episodes. BD2 patients had a higher mtDNA copy number than controls. Thus, changes in mitochondrial function may influence BD pathophysiology. The opposite directions of the association with mtDNA copy number in BD1 and BD2 patients suggests that the difference in pathophysiology may be associated with mitochondrial function.

Original languageEnglish
Pages (from-to)325-333
Number of pages9
JournalJournal of Psychiatric Research
Volume145
DOIs
StatePublished - Jan 2022

Keywords

  • Bipolar I disorder
  • Bipolar II disorder
  • Mitochondrial DNA copy number

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