Differences in brain surface area and cortical volume between suicide attempters and non-attempters with major depressive disorder

Seung Gul Kang, Seo Eun Cho, Kyoung Sae Na, Jung Sun Lee, Sung Woo Joo, Seong Jin Cho, Young Don Son, Yu Jin Lee

Research output: Contribution to journalArticle

Abstract

The neurobiological causes underlying suicidal behaviors in major depressive disorder (MDD) have not been identified. This study was performed to investigate the differences in brain cortical thickness, surface area, and volume between suicide attempters and non-attempters with MDD. We performed magnetic resonance imaging (MRI) in 38 MDD patients (18–65 years old; 18 male, 20 female) with and without a history of suicide attempts. FreeSurfer software was used to compare the cortical thickness, surface area, and volume of 19 suicide attempters with MDD and 19 suicide non-attempters with MDD, while controlling for age, sex, mean area (or volume), and severity of depression. Compared with suicide non-attempters, suicide attempters with MDD exhibited a larger surface area in the left postcentral area and left lateral occipital area and a larger cortical volume in the left postcentral area and left lateral orbitofrontal area. Suicide attempters exhibited a smaller surface area in the left superior frontal area than suicide non-attempters. The present findings provide evidence for neuroanatomical risk factors of suicide in MDD. Further research to replicate these results and determine the mechanisms underlying these findings is needed.

Original languageEnglish
Article number111032
JournalPsychiatry Research - Neuroimaging
Volume297
DOIs
StatePublished - 30 Mar 2020

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Keywords

  • Cortical volume
  • FreeSurfer
  • Major depressive disorder
  • Suicide attempt
  • Surface area

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