Diagnostic Performance, Stability, and Usability of Self-Collected Combo Swabs and Saliva for Coronavirus Disease 2019 Diagnosis: A Case-Control Study

Seong Jin Choi, Jongtak Jung, Eu Suk Kim, Hong Bin Kim, Jeong Su Park, Kyoung Un Park, Hyunju Lee, Eunyoung Lee, Pyoeng Gyun Choe, Ji Yeon Kim, Eun Joo Lee, Kyoung Ho Song

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Self-sampling procedures to detect severe acute respiratory syndrome coronavirus 2 is important for patients who have difficulty visiting the hospital and may decrease the burden for health care workers (HCWs). The objective of this study was to evaluate the diagnostic performance, stability and usability of self-collected nasal and oral combo swabs and saliva specimens. Materials and Methods: We conducted a case-control study with 50 patients with coronavirus disease 2019 (COVID-19) and 50 healthy volunteers from March, 2021 to June, 2021. We performed real-time reverse-transcription polymerase chain reaction to compare the diagnostic performance of self-collected specimens using positive percent agreements (PPAs). Results: The PPAs between self-collected and HCW-collected specimens were 77.3-81.0% and 80.5-86.7% for the combo swabs and saliva specimens, respectively. The PPAs increased to 88.9-89.2% and 81.2-82.1% with a cycle threshold value ≤30. Conclusion: The diagnostic performance of self sampling was comparable to that of HCW sampling in patients with high viral loads and may thus assist in the early diagnosis of COVID-19.

Original languageEnglish
Pages (from-to)517-528
Number of pages12
JournalInfection and Chemotherapy
Volume54
Issue number3
DOIs
StatePublished - Sep 2022
Externally publishedYes

Keywords

  • COVID-19
  • SARS-CoV-2
  • Self sampling
  • Self-collected specimens

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