Diagnostic performance of 18F-FDG-labeled white blood cell PET/CT for cyst infection in patients with autosomal dominant polycystic kidney disease: A prospective study

Hyun Woo Kwon, Ho Young Lee, Young Hwan Hwang, Hayne Cho Park, Curie Ahn, Keon Wook Kang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objectives Cyst infection (CI) is a common problem in patients with autosomal dominant polycystic kidney disease (ADPKD) and the accurate detection of infected cysts is very important. We evaluated the diagnostic performance of fluorine-18 fluorodeoxyglucose-labeled white blood cell (WBC) PET/computed tomography (CT) for detection of infected cysts in patients with ADPKD. Patients and methods Seventeen patients with ADPKD (male : female, 6 : 11; age, 53 ± 9 years) and suspected CI were enrolled in this prospective study. Patients were classified as having definite/probable/possible CI. All patients underwent WBC PET/CT within 2 days of starting antibiotic treatment. The degree of WBC accumulation was evaluated qualitatively by nuclear medicine physicians. The diagnostic performance of WBC PET/CT was evaluated by sensitivity, specificity, positive predictive values, and negative predictive values. These values were compared with those generated from CT scans and MRI. Results Seven patients were classified as having renal CI (definite 6, probable 1). In this group, WBC PET/CT showed six positive findings and one equivocal finding. Seven patients were diagnosed with possible infection. In this group, WBC PET/CT showed six negative findings and one indeterminate finding. The diagnostic performance of WBC PET/CT showed advantages over CT or MRI scans (sensitivity 85.7%, specificity 87.5%, positive predictive value 85.7%, negative predictive value 87.5%). Conclusion This prospective study shows that WBC PET/CT can provide an accurate diagnosis of CI in patients with ADPKD.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalNuclear Medicine Communications
Volume37
Issue number5
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Autosomal dominant polycystic kidney disease
  • Cyst infection
  • WBC PET/CT
  • White blood cell

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