Diagnostic accuracy of multi-/single-detector row CT and contrast-enhanced MRI in the detection of hepatocellular carcinomas meeting the Milan criteria before liver transplantation

Se Hyung Kim, Byung Ihn Choi, Jae Young Lee, Soo Jin Kim, Young Ho So, Hyo Won Eun, Jeong Min Lee, Joon Koo Han

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Liver transplantation has been considered to be the only causal treatment for liver cirrhosis patients with hepatocellular carcinoma (HCC) due to its theoretical advantage of eliminating both the tumor and liver disease. However, because of the shortage of donor organs, it is strongly recommended that liver transplantations should be performed on cirrhotic patients with HCCs only when the patients meet the predetermined criteria in terms of number and extent of HCCs. Imaging is thus decisive in the patient inclusion or exclusion from transplantation lists. The imaging techniques used are CT, MRI and ultrasonography. The latter has been proven to be ineffective for HCC surveillance in transplant recipients because of its heavy operator dependence and unreliable detection of small and intermediately sized HCCs. The purpose of this article, then, is to systematically review the diagnostic performances of single-/multidetector row CT, dynamic gadolinium-enhanced MRI, superparamagnetic iron oxide (SPIO)-enhanced MRI and double-contrast MRI using both gadolinium and SPIO for the detection of HCCs with special emphasis on liver transplantation.

Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalIntervirology
Volume51
Issue numberSUPPL. 1
DOIs
StatePublished - 1 Jun 2008

Keywords

  • Diagnostic performance
  • Dysplastic nodule
  • Hepatocellular carcinoma
  • Liver transplantation
  • MRI
  • Multidetector CT
  • Single-detector CT

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