Diabetes mellitus and risk of thyroid cancer: A meta-analysis

Yohwan Yeo, Seung Hyun Ma, Yunji Hwang, Pamela L. Horn-Ross, Ann Hsing, Kyu Eun Lee, Young Joo Park, Do Joon Park, Keun Young Yoo, Sue K. Park

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Introduction: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. Methods: We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM. Results: Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11-1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08-1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13-1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80-1.53). Conclusions: Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.

Original languageEnglish
Article numbere98135
JournalPLoS ONE
Volume9
Issue number6
DOIs
StatePublished - 13 Jun 2014

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Medical problems
diabetes mellitus
Thyroid Neoplasms
meta-analysis
Meta-Analysis
Diabetes Mellitus
Endocrine Gland Neoplasms
thyroid neoplasms
neoplasms
risk estimate
testing
systematic review
case-control studies
Bibliographies
Bibliography
diabetes
MEDLINE
risk factors
Case-Control Studies
incidence

Cite this

Yeo, Yohwan ; Ma, Seung Hyun ; Hwang, Yunji ; Horn-Ross, Pamela L. ; Hsing, Ann ; Lee, Kyu Eun ; Park, Young Joo ; Park, Do Joon ; Yoo, Keun Young ; Park, Sue K. / Diabetes mellitus and risk of thyroid cancer : A meta-analysis. In: PLoS ONE. 2014 ; Vol. 9, No. 6.
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abstract = "Introduction: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. Methods: We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM. Results: Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95{\%} CI 1.11-1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95{\%} CIs 1.08-1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95{\%} CI 1.13-1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95{\%} CI 0.80-1.53). Conclusions: Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.",
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Diabetes mellitus and risk of thyroid cancer : A meta-analysis. / Yeo, Yohwan; Ma, Seung Hyun; Hwang, Yunji; Horn-Ross, Pamela L.; Hsing, Ann; Lee, Kyu Eun; Park, Young Joo; Park, Do Joon; Yoo, Keun Young; Park, Sue K.

In: PLoS ONE, Vol. 9, No. 6, e98135, 13.06.2014.

Research output: Contribution to journalArticle

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T1 - Diabetes mellitus and risk of thyroid cancer

T2 - A meta-analysis

AU - Yeo, Yohwan

AU - Ma, Seung Hyun

AU - Hwang, Yunji

AU - Horn-Ross, Pamela L.

AU - Hsing, Ann

AU - Lee, Kyu Eun

AU - Park, Young Joo

AU - Park, Do Joon

AU - Yoo, Keun Young

AU - Park, Sue K.

PY - 2014/6/13

Y1 - 2014/6/13

N2 - Introduction: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. Methods: We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM. Results: Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11-1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08-1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13-1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80-1.53). Conclusions: Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.

AB - Introduction: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. Methods: We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM. Results: Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11-1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08-1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13-1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80-1.53). Conclusions: Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.

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VL - 9

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Yeo Y, Ma SH, Hwang Y, Horn-Ross PL, Hsing A, Lee KE et al. Diabetes mellitus and risk of thyroid cancer: A meta-analysis. PLoS ONE. 2014 Jun 13;9(6). e98135. https://doi.org/10.1371/journal.pone.0098135