Development of small-animal PET prototype using silicon photomultiplier (SiPM): Initial results of phantom and animal imaging studies

Sun Il Kwon, Jae Sung Lee, Hyun Suk Yoon, Mikiko Ito, Guen Bae Ko, Jae Yeon Choi, Sung Hyuk Lee, In Chan Song, Jae Min Jeong, Dong Soo Lee, Seong Jong Hong

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Silicon photomultiplier (SiPM; also called a Geiger-mode avalanche photodiode) is a promising semiconductor photosensor in PET and PET/MRI because it is intrinsically MRI-compatible and has internal gain and timing properties comparable to those of a photomultiplier tube. In this study, we have developed a smallanimal PET system using SiPMs and lutetium gadolinium oxyorthosilicate (LGSO) crystals and performed physical evaluation and animal imaging studies to show the feasibility of this system. Methods: The SiPM PET system consists of 8 detectors, each of which comprises 2×6 SiPMs and 4×13 LGSO crystals. Each crystal has dimensions of 1.5×1.5×7 mm. The crystal face-toface diameter and axial field of view are 6.0 cm and 6.5 mm, respectively. Bias voltage is applied to each SiPM using a finely controlled voltage supply because the gain of the SiPM strongly depends on the supply voltage. The physical characteristics were studied by measuring energy resolution, sensitivity, and spatial resolution. Various mouse and rat images were obtained to study the feasibility of the SiPM PET system in in vivo animal studies. Reconstructed PET images using a maximum-likelihood expectation maximization algorithm were coregistered with animal CT images. Results: All individual LGSO crystals within the detectors were clearly distinguishable in flood images obtained by irradiating the detector using a 22Na point source. The energy resolution for individual crystals was 25.8%±2.6% on average for 511-keV photopeaks. The spatial resolution measured with the 22Na point source in a warm background was 1.0 mm (2 mm off-center) and 1.4 mm (16 mm off-center) when the maximum-likelihood expectation maximization algorithm was applied. A myocardial 18F-FDG study in mice and a skeletal 18F study in rats demonstrated the fine spatial resolution of the scanner. The feasibility of the SiPM PET system was also confirmed in the tumor images of mice using 18F-FDG and 68Ga-RGD and in the brain images of rats using 18F-FDG. Conclusion: These results indicate that it is possible to develop a PET system using a promising semiconductor photosensor, which yielded reasonable PET performance in phantom and animal studies.

Original languageEnglish
Pages (from-to)572-579
Number of pages8
JournalJournal of Nuclear Medicine
Volume52
Issue number4
DOIs
StatePublished - 1 Apr 2011

Keywords

  • Geiger-mode APD (G-APD)
  • PE.T.
  • PET/MRI
  • Semi-conductor photo-sensor
  • Silicon photomultiplier (SiPM)

Cite this