Development of Korean standard brain templates

Jae Sung Lee, Dong Soo Lee, Jinsu Kim, Yu Kyeong Kim, Eunjoo Kang, Hyejin Kang, Keon Wook Kang, Min Lee Jong, Jae Jin Kim, Hae Jeong Park, Jun Soo Kwon, I. Kim Sun, Woo Yoo Tae, Kee Hyun Chang, Chul Lee Myung

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We developed age, gender and ethnic specific brain templates based on MR and Positron-Emission Tomography (PET) images of Korean normal volunteers. Seventy-eight normal right-handed volunteers (M/F=49/29) underwent 3D T1-weighted SPGR MR and F-18-FDG PET scans. For the generation of standard templates, an optimal target brain that has the average global hemispheric shape was selected for each gender. MR images were then spatially normalized by linear transformation to the target brains, and normalization parameters were reapplied to PET images. Subjects were subdivided into 2 groups for each gender: the young/midlife (<55 yr) and the elderly groups. Young and elderly MRI/PET templates were composed by averaging the spatially normalized images. Korean templates showed different shapes and sizes (mean length, width, and height of the brains were 16.5, 14.3 and 12.1 cm for man, and 15.6, 13.5 and 11.4 cm for woman) from the template based on Caucasian (18.3, 14.2, and 13.3 cm). MRI and PET templates developed in this study will provide the framework for more accurate stereotactic standardization and anatomical localization.

Original languageEnglish
Pages (from-to)483-488
Number of pages6
JournalJournal of Korean Medical Science
Volume20
Issue number3
StatePublished - 1 Jun 2005

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Keywords

  • Atlases
  • Brain
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography
  • Reference Standards

Cite this

Lee, J. S., Lee, D. S., Kim, J., Kim, Y. K., Kang, E., Kang, H., ... Myung, C. L. (2005). Development of Korean standard brain templates. Journal of Korean Medical Science, 20(3), 483-488.
Lee, Jae Sung ; Lee, Dong Soo ; Kim, Jinsu ; Kim, Yu Kyeong ; Kang, Eunjoo ; Kang, Hyejin ; Kang, Keon Wook ; Jong, Min Lee ; Kim, Jae Jin ; Park, Hae Jeong ; Kwon, Jun Soo ; Sun, I. Kim ; Tae, Woo Yoo ; Chang, Kee Hyun ; Myung, Chul Lee. / Development of Korean standard brain templates. In: Journal of Korean Medical Science. 2005 ; Vol. 20, No. 3. pp. 483-488.
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author = "Lee, {Jae Sung} and Lee, {Dong Soo} and Jinsu Kim and Kim, {Yu Kyeong} and Eunjoo Kang and Hyejin Kang and Kang, {Keon Wook} and Jong, {Min Lee} and Kim, {Jae Jin} and Park, {Hae Jeong} and Kwon, {Jun Soo} and Sun, {I. Kim} and Tae, {Woo Yoo} and Chang, {Kee Hyun} and Myung, {Chul Lee}",
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Lee, JS, Lee, DS, Kim, J, Kim, YK, Kang, E, Kang, H, Kang, KW, Jong, ML, Kim, JJ, Park, HJ, Kwon, JS, Sun, IK, Tae, WY, Chang, KH & Myung, CL 2005, 'Development of Korean standard brain templates', Journal of Korean Medical Science, vol. 20, no. 3, pp. 483-488.

Development of Korean standard brain templates. / Lee, Jae Sung; Lee, Dong Soo; Kim, Jinsu; Kim, Yu Kyeong; Kang, Eunjoo; Kang, Hyejin; Kang, Keon Wook; Jong, Min Lee; Kim, Jae Jin; Park, Hae Jeong; Kwon, Jun Soo; Sun, I. Kim; Tae, Woo Yoo; Chang, Kee Hyun; Myung, Chul Lee.

In: Journal of Korean Medical Science, Vol. 20, No. 3, 01.06.2005, p. 483-488.

Research output: Contribution to journalArticle

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AU - Lee, Jae Sung

AU - Lee, Dong Soo

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AU - Kang, Eunjoo

AU - Kang, Hyejin

AU - Kang, Keon Wook

AU - Jong, Min Lee

AU - Kim, Jae Jin

AU - Park, Hae Jeong

AU - Kwon, Jun Soo

AU - Sun, I. Kim

AU - Tae, Woo Yoo

AU - Chang, Kee Hyun

AU - Myung, Chul Lee

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N2 - We developed age, gender and ethnic specific brain templates based on MR and Positron-Emission Tomography (PET) images of Korean normal volunteers. Seventy-eight normal right-handed volunteers (M/F=49/29) underwent 3D T1-weighted SPGR MR and F-18-FDG PET scans. For the generation of standard templates, an optimal target brain that has the average global hemispheric shape was selected for each gender. MR images were then spatially normalized by linear transformation to the target brains, and normalization parameters were reapplied to PET images. Subjects were subdivided into 2 groups for each gender: the young/midlife (<55 yr) and the elderly groups. Young and elderly MRI/PET templates were composed by averaging the spatially normalized images. Korean templates showed different shapes and sizes (mean length, width, and height of the brains were 16.5, 14.3 and 12.1 cm for man, and 15.6, 13.5 and 11.4 cm for woman) from the template based on Caucasian (18.3, 14.2, and 13.3 cm). MRI and PET templates developed in this study will provide the framework for more accurate stereotactic standardization and anatomical localization.

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