Detection of anti-B antibodies in a patient with A1B blood group: A case report and literature review

Hee Jeong Youk, Jin Seok Kim, Hyungsuk Kim, Sang Hyun Hwang, Heung Bum Oh, Yousun Chung, Dae Hyun Ko

Research output: Contribution to journalArticlepeer-review

Abstract

ABO antibodies occur naturally and usually exist as alloantibodies. They are the most clinically significant in cases of transfusions. However, there are very few reports on auto-anti-A or B. A 58-year-old man visited our hospital for evaluation of an inguinal mass. Blood typing was performed, while preparing the patient for an excisional biopsy. Forward and reverse typing showed a typical AB and A pattern. Results of the direct antiglobulin and unexpected antibody screening tests were negative. The serum did not react with AB3 cells. The biopsy revealed a diffuse large B-cell lymphoma. After completing four cycles of R-CHOP chemotherapy, the patient achieved complete remission. There were no anti-B antibodies found on repeat ABO typing. This report shares our experience on unexpected anti-B antibody findings in a patient with an A1B blood type. To the best of our knowledge, this is the first report of anti-B antibodies in a patient with an A1B blood type in Korea.

Original languageEnglish
Article number103450
JournalTransfusion and Apheresis Science
Volume61
Issue number5
DOIs
StatePublished - Oct 2022
Externally publishedYes

Keywords

  • ABO blood group
  • ABO discrepancy
  • Anti-B
  • Blood group typing

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