Decreased thalamic volumes in adolescent inhalant users from Korea and Australia

Soon Beom Hong, Eun Jung Choi, Ho Hyun Kim, Jeong Eun Suh, Michael J. Takagi, Dan I. Lubman, Jae-Won Kim, Chang Dai Kim, Soon Hyung Yi, Murat Yücel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives. Research investigating the impact of inhalant misuse on brain structure suggests abnormalities in subcortical regions. We investigated the association between inhalant misuse and subcortical brain volumes in adolescents. Methods. Based on a collaborative dataset from South Korea (inhalant users: N = 15, mean age = 16.7, SD = 1.1; controls: N = 15, mean age = 15.4, SD = 1.2) and Australia (inhalant users: N = 7, mean age = 18.2, SD = 1.4; controls: N = 7, mean age = 18.9, SD = 2.6), the volumes of caudate nucleus, putamen, pallidum, amygdala, hippocampus, and thalamus were estimated in adolescent inhalant users and healthy adolescents using FreeSurfer. Results. The results revealed a significantly decreased right thalamic volume in adolescent inhalant users (P = 0.042), along with a trend-level decrease in left thalamic volume (P = 0.061). A negative correlation (r =-0.544; P = 0.036) between thalamic volume and severity of inhalant use (i.e., reduced volumes associated with greater use) was identified among Korean participants. Conclusions. These findings suggest that compared with other subcortical structures, the thalamus is particularly sensitive to damage following chronic inhalant exposure during adolescence.

Original languageEnglish
Pages (from-to)636-640
Number of pages5
JournalWorld Journal of Biological Psychiatry
Volume15
Issue number8
DOIs
StatePublished - 1 Dec 2014

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Korea
Thalamus
Republic of Korea
Globus Pallidus
Caudate Nucleus
Putamen
Brain
Amygdala
Hippocampus
Research

Keywords

  • Adolescent
  • Inhalant misuse
  • Magnetic resonance imaging
  • Subcortical volume
  • Thalamus

Cite this

Hong, Soon Beom ; Choi, Eun Jung ; Kim, Ho Hyun ; Suh, Jeong Eun ; Takagi, Michael J. ; Lubman, Dan I. ; Kim, Jae-Won ; Kim, Chang Dai ; Yi, Soon Hyung ; Yücel, Murat. / Decreased thalamic volumes in adolescent inhalant users from Korea and Australia. In: World Journal of Biological Psychiatry. 2014 ; Vol. 15, No. 8. pp. 636-640.
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abstract = "Objectives. Research investigating the impact of inhalant misuse on brain structure suggests abnormalities in subcortical regions. We investigated the association between inhalant misuse and subcortical brain volumes in adolescents. Methods. Based on a collaborative dataset from South Korea (inhalant users: N = 15, mean age = 16.7, SD = 1.1; controls: N = 15, mean age = 15.4, SD = 1.2) and Australia (inhalant users: N = 7, mean age = 18.2, SD = 1.4; controls: N = 7, mean age = 18.9, SD = 2.6), the volumes of caudate nucleus, putamen, pallidum, amygdala, hippocampus, and thalamus were estimated in adolescent inhalant users and healthy adolescents using FreeSurfer. Results. The results revealed a significantly decreased right thalamic volume in adolescent inhalant users (P = 0.042), along with a trend-level decrease in left thalamic volume (P = 0.061). A negative correlation (r =-0.544; P = 0.036) between thalamic volume and severity of inhalant use (i.e., reduced volumes associated with greater use) was identified among Korean participants. Conclusions. These findings suggest that compared with other subcortical structures, the thalamus is particularly sensitive to damage following chronic inhalant exposure during adolescence.",
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Hong, SB, Choi, EJ, Kim, HH, Suh, JE, Takagi, MJ, Lubman, DI, Kim, J-W, Kim, CD, Yi, SH & Yücel, M 2014, 'Decreased thalamic volumes in adolescent inhalant users from Korea and Australia', World Journal of Biological Psychiatry, vol. 15, no. 8, pp. 636-640. https://doi.org/10.3109/15622975.2014.902540

Decreased thalamic volumes in adolescent inhalant users from Korea and Australia. / Hong, Soon Beom; Choi, Eun Jung; Kim, Ho Hyun; Suh, Jeong Eun; Takagi, Michael J.; Lubman, Dan I.; Kim, Jae-Won; Kim, Chang Dai; Yi, Soon Hyung; Yücel, Murat.

In: World Journal of Biological Psychiatry, Vol. 15, No. 8, 01.12.2014, p. 636-640.

Research output: Contribution to journalArticle

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AU - Hong, Soon Beom

AU - Choi, Eun Jung

AU - Kim, Ho Hyun

AU - Suh, Jeong Eun

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AU - Lubman, Dan I.

AU - Kim, Jae-Won

AU - Kim, Chang Dai

AU - Yi, Soon Hyung

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