Cytochrome C oxidase subunit 1, internal transcribed spacer 1, nicotinamide adenine dinucleotide hydrogen dehydrogenase subunits 2 and 5 of Clonorchis sinensis ancient DNA retrieved from Joseon Dynasty mummy specimens

Jong Ha Hong, Chang Seok Oh, Jong Yil Chai, Min Seo, Dong Hoon Shin

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Abstract

We analyzed Clonorchis sinensis ancient DNA (aDNA) acquired from the specimens of the Joseon mummies. The target regions were cytochrome C oxidase subunit 1 (CO1), internal transcribed spacer 1 (ITS1), nicotinamide adenine dinucleotide hydrogen (NADH) dehydrogenase subunits 2 (NAD2) and 5 (NAD5). The sequences of C. sinensis aDNA was completely or almost identical to modern C. sinensis sequences in GenBank. We also found that ITS1, NAD2 and NAD5 could be good markers for molecular diagnosis between C. sinensis and the other trematode parasite species. The current result could improve our knowledge about genetic history of C. sinensis.

Original languageEnglish
Article numbere149
JournalJournal of Korean Medical Science
Volume34
Issue number20
DOIs
StatePublished - 27 May 2019

Bibliographical note

Publisher Copyright:
© 2019 The Korean Academy of Medical Sciences.

Keywords

  • Ancient DNA
  • Clonorchis sinensis
  • Mummies
  • Phylogenetic Analysis
  • Republic of Korea

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