Cynanchum wilfordii etanolic extract controls blood cholesterol: A double-blind, randomized, placebo-controlled, parallel trial

Ji Sun Youn, Young Min Ham, Weon Jong Yoon, Ho Chun Choi, Ji Eun Lee, Belong Cho, Ji Yeon Kim

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We evaluated the effects of Cynanchum wilfordii (CW) ethanolic extract on blood cholesterol levels in adults with high low-density lipoprotein cholesterol (LDL-C) levels. In a double-blind, randomized, placebo-controlled, parallel trial, 84 subjects were recruited. Participants were randomly divided into two groups with a low-dose (300 mg/d) or high-dose (600 mg/d) of CW. Levels of very low-density lipoprotein (p = 0.022) and triglycerides (p = 0.022) were significantly lower in the low-dose CW group than in the placebo group after 8 weeks. In a subgroup of participants with LDL-C≥ 150 mg/dL (n = 33), there was a significant decrease in total cholesterol (low-dose, p = 0.012; high-dose, p = 0.021), apolipoprotein B (low-dose, p = 0.022; high-dose, p =0.016), and cholesteryl ester transfer protein (low-dose, p = 0.037; high-dose, p = 0.016) after 8 weeks of CW. The correlation between changes in total cholesterol and baseline LDL-C levels was significant in the groups that received both doses of CW (low-dose, p = 0.010; high-dose, p = 0.015). These results show that the CW ethanolic extract can regulate blood cholesterol in subjects with LDL-C≥ 150 mg/dL.

Original languageEnglish
Article number836
JournalNutrients
Volume11
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • Blood cholesterol
  • Clinical trial
  • Cynanchum wilfordii
  • Hyperlipidemia
  • LDL-cholesterol

Fingerprint Dive into the research topics of 'Cynanchum wilfordii etanolic extract controls blood cholesterol: A double-blind, randomized, placebo-controlled, parallel trial'. Together they form a unique fingerprint.

  • Cite this