@inproceedings{6acafe4eba5b41f8a58d6b876d0b98a9,
title = "Cyclooxygenase-2 expression in cervical intraepithelial neoplasia",
abstract = "To evaluate the role of cyclooxygenase (COX)-2 during cervical carcinogenesis, we investigated COX-2 expression in the dysplastic epithelium and stromal cells of cervical intraepithelial neoplasia (CIN). Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute. COX-2 expression was evaluated separately in the dysplastic epithelium and stromal cells of CIN. The relationships between COX-2 expression and clinicopathologic variables were examined. For the dysplastic epithelium, COX-2 expression was negative in 137 (92.6%) and positive in 11 (7.4%) specimens. For the stromal cells, COX-2 expression was negative in all specimens. The COX-2 expression in dysplastic epithelium was higher in older (P = 0.038) or postmenopausal (P = 0.025) women. In conclusion, COX-2 expression was observed only in the dysplastic epithelium but not in the stromal cells of CIN. The COX-2 expression in dysplastic epithelium was associated with age and menopausal status.",
keywords = "Age factors, Cervical intraepithelial neoplasia (CIN), Cyclooxygenase-2, Epithelium, Menopause, Stromal cells",
author = "Kidong Kim and Jeon, {Yong Tark} and Park, {In Ae} and Kim, {Jae Weon} and Park, {Noh Hyun} and Kang, {Soon Beom} and Lee, {Hyo Pyo} and Song, {Yong Sang}",
year = "2009",
month = aug,
doi = "10.1111/j.1749-6632.2009.04724.x",
language = "English",
isbn = "9781573317375",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "111--115",
booktitle = "Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways",
}