CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia

Jiwoong Choi, Kum Ju Chae, Gong Yong Jin, Ching Long Lin, Archana T. Laroia, Eric A. Hoffman, Chang Hyun Lee

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1 Scopus citations

Abstract

We applied quantitative CT image matching to assess the degree of motion in the idiopathic ILD such as usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Twenty-one normal subjects and 42 idiopathic ILD (31 UIP and 11 NSIP) patients were retrospectively included. Inspiratory and expiratory CT images, reviewed by two experienced radiologists, were used to compute displacement vectors at local lung regions matched by image registration. Normalized three-dimensional and two-dimensional (dorsal-basal) displacements were computed at a sub-acinar scale. Displacements, volume changes, and tissue fractions in the whole lung and the lobes were compared between normal, UIP, and NSIP subjects. The dorsal-basal displacement in lower lobes was smaller in UIP patients than in NSIP or normal subjects (p = 0.03, p = 0.04). UIP and NSIP were not differentiated by volume changes in the whole lung or upper and lower lobes (p = 0.53, p = 0.12, p = 0.97), whereas the lower lobe air volume change was smaller in both UIP and NSIP than normal subjects (p = 0.02, p = 0.001). Regional expiratory tissue fractions and displacements showed positive correlations in normal and UIP subjects but not in NSIP subjects. In summary, lung motionography quantified by image registration-based lower lobe dorsal-basal displacement may be used to assess the degree of motion, reflecting limited motion due to fibrosis in the ILD such as UIP and NSIP.

Original languageEnglish
Article number867473
JournalFrontiers in Physiology
Volume13
DOIs
StatePublished - 4 Oct 2022
Externally publishedYes

Keywords

  • computational biomechanics
  • computed tomography
  • idiopathic pulmonary fibrosis
  • image registration
  • interstitial lung disease
  • lung motionography
  • quantitative computed tomography image matching
  • usual interstitial pneumonia

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