Crohn’s disease and ulcerative colitis are associated with different lipid profile disorders: a nationwide population-based study

Hosim Soh, Jong Pil Im, Kyungdo Han, Seona Park, Seung Wook Hong, Jeong Min Moon, Eun Ae Kang, Jaeyoung Chun, Hyun Jung Lee, Joo Sung Kim

Research output: Contribution to journalArticle

Abstract

Background: The relationships between lipid profiles and IBD remain elusive. Aim: To determine the association of IBD with serum lipid profiles. Methods: A nationwide population-based study was performed using claims data from the Korean National Healthcare Insurance service. A total of 9 706 026 subjects undergoing medical check-ups in 2009 were enrolled and followed up until 2016. Individuals who developed Crohn's disease (CD) or ulcerative colitis (UC) were identified during follow-up. Adjusted hazard ratio (aHR) by age, sex, body mass index, cigarette smoking, alcohol drinking, exercise, income and underlying comorbidities was calculated to define the impact of serum lipid profiles on developing IBD. Results: During a median follow-up of 7.3 years, IBD was detected in 7,058 (0.07%) individuals. Compared with the highest quartile of serum total cholesterol (TC) levels, lower TC levels were associated with higher incidence of CD (aHR: Q1, 2.52; Q2, 1.52; Q3, 1.27), but not UC. Lower serum LDL-C levels were associated with higher incidence of CD (aHR: Q1, 1.92; Q2, 1.47; Q3, 1.22), but not UC. Moreover, lower serum HDL-C levels were associated with higher incidence of CD (aHR: Q1, 2.49; Q2, 1.90; Q3, 1.43), but not UC. In contrast, lower serum triglyceride levels were associated with higher incidence of UC (aHR: Q1, 1.22; Q2, 1.19; Q3, 1.19), but not CD. Conclusions: Low serum TC, LDL-C and HDL-C levels were associated with CD. Low serum triglyceride levels were related to UC.

Original languageEnglish
Pages (from-to)446-456
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume51
Issue number4
DOIs
StatePublished - 1 Feb 2020

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Ulcerative Colitis
Crohn Disease
Lipids
Serum
Population
Incidence
Triglycerides
Cholesterol
Sex Ratio
Insurance
Alcohol Drinking
LDL Cholesterol
HDL Cholesterol
Comorbidity
Body Mass Index
Smoking
Delivery of Health Care

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Soh, Hosim ; Im, Jong Pil ; Han, Kyungdo ; Park, Seona ; Hong, Seung Wook ; Moon, Jeong Min ; Kang, Eun Ae ; Chun, Jaeyoung ; Lee, Hyun Jung ; Kim, Joo Sung. / Crohn’s disease and ulcerative colitis are associated with different lipid profile disorders : a nationwide population-based study. In: Alimentary Pharmacology and Therapeutics. 2020 ; Vol. 51, No. 4. pp. 446-456.
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abstract = "Background: The relationships between lipid profiles and IBD remain elusive. Aim: To determine the association of IBD with serum lipid profiles. Methods: A nationwide population-based study was performed using claims data from the Korean National Healthcare Insurance service. A total of 9 706 026 subjects undergoing medical check-ups in 2009 were enrolled and followed up until 2016. Individuals who developed Crohn's disease (CD) or ulcerative colitis (UC) were identified during follow-up. Adjusted hazard ratio (aHR) by age, sex, body mass index, cigarette smoking, alcohol drinking, exercise, income and underlying comorbidities was calculated to define the impact of serum lipid profiles on developing IBD. Results: During a median follow-up of 7.3 years, IBD was detected in 7,058 (0.07{\%}) individuals. Compared with the highest quartile of serum total cholesterol (TC) levels, lower TC levels were associated with higher incidence of CD (aHR: Q1, 2.52; Q2, 1.52; Q3, 1.27), but not UC. Lower serum LDL-C levels were associated with higher incidence of CD (aHR: Q1, 1.92; Q2, 1.47; Q3, 1.22), but not UC. Moreover, lower serum HDL-C levels were associated with higher incidence of CD (aHR: Q1, 2.49; Q2, 1.90; Q3, 1.43), but not UC. In contrast, lower serum triglyceride levels were associated with higher incidence of UC (aHR: Q1, 1.22; Q2, 1.19; Q3, 1.19), but not CD. Conclusions: Low serum TC, LDL-C and HDL-C levels were associated with CD. Low serum triglyceride levels were related to UC.",
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Crohn’s disease and ulcerative colitis are associated with different lipid profile disorders : a nationwide population-based study. / Soh, Hosim; Im, Jong Pil; Han, Kyungdo; Park, Seona; Hong, Seung Wook; Moon, Jeong Min; Kang, Eun Ae; Chun, Jaeyoung; Lee, Hyun Jung; Kim, Joo Sung.

In: Alimentary Pharmacology and Therapeutics, Vol. 51, No. 4, 01.02.2020, p. 446-456.

Research output: Contribution to journalArticle

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AU - Soh, Hosim

AU - Im, Jong Pil

AU - Han, Kyungdo

AU - Park, Seona

AU - Hong, Seung Wook

AU - Moon, Jeong Min

AU - Kang, Eun Ae

AU - Chun, Jaeyoung

AU - Lee, Hyun Jung

AU - Kim, Joo Sung

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N2 - Background: The relationships between lipid profiles and IBD remain elusive. Aim: To determine the association of IBD with serum lipid profiles. Methods: A nationwide population-based study was performed using claims data from the Korean National Healthcare Insurance service. A total of 9 706 026 subjects undergoing medical check-ups in 2009 were enrolled and followed up until 2016. Individuals who developed Crohn's disease (CD) or ulcerative colitis (UC) were identified during follow-up. Adjusted hazard ratio (aHR) by age, sex, body mass index, cigarette smoking, alcohol drinking, exercise, income and underlying comorbidities was calculated to define the impact of serum lipid profiles on developing IBD. Results: During a median follow-up of 7.3 years, IBD was detected in 7,058 (0.07%) individuals. Compared with the highest quartile of serum total cholesterol (TC) levels, lower TC levels were associated with higher incidence of CD (aHR: Q1, 2.52; Q2, 1.52; Q3, 1.27), but not UC. Lower serum LDL-C levels were associated with higher incidence of CD (aHR: Q1, 1.92; Q2, 1.47; Q3, 1.22), but not UC. Moreover, lower serum HDL-C levels were associated with higher incidence of CD (aHR: Q1, 2.49; Q2, 1.90; Q3, 1.43), but not UC. In contrast, lower serum triglyceride levels were associated with higher incidence of UC (aHR: Q1, 1.22; Q2, 1.19; Q3, 1.19), but not CD. Conclusions: Low serum TC, LDL-C and HDL-C levels were associated with CD. Low serum triglyceride levels were related to UC.

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