Correlation of temporal lobe glucose metabolism with the Wada memory test

Bong Hong Seung Bong Hong, Young Roh Suk Young Roh, Sang Eun Kim, Won Seo Dae Won Seo

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17 Scopus citations

Abstract

Purpose: The goal of the present study was to examine the relationship of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and the Wada memory test in lateralizing memory dominance and epileptic focus. Methods: FDG-PET and the Wada test were performed in 18 patients with temporal lobe epilepsy (TLE). The asymmetry indices of FDG-PET (PET-AI) were calculated in mesial, polar, anterolateral, midlateral, and posterolateral regions of the temporal lobe, and those of Wada memory test (Wada-AI) were obtained as well. Results: The Wada-AI was significantly correlated with PET-AI in mesial (r = 0.67, p = 0.003), polar (r = 0.55, p = 0.019), anterolateral (r = 0.55, p = 0.019), and midlateral (r = 0.51, p = 0.031) regions of the temporal lobe. However, after a linear regression analysis, PET-AI of only the mesial temporal region was significantly correlated with Wada-AI (p = 0.008). Wada-AI could correctly lateralize the seizure focus in 90% of the left TLE and 75% of the right TLE patients. The PET-AI of the mesial temporal region showed the highest sensitivity of seizure lateralization (80% of left TLE and 87.5% of right TLE). PET-AI of other temporal regions had lower sensitivities (50-80% of left TLE, 20-75% of right TLE). One or two patients showed false seizure lateralization by PET-AI on each temporal region. Conclusions: Although FDG-PET hypometabolism is observed at both mesial and lateral regions of the temporal lobe in mesial TLE, mesial temporal region appeared to be a dominant and leading area for lateralizing Wada memory dominance and epileptic focus.

Original languageEnglish
Pages (from-to)1554-1559
Number of pages6
JournalEpilepsia
Volume41
Issue number12
DOIs
StatePublished - 1 Jan 2000

Keywords

  • Asymmetry index
  • Cerebral glucose metabolism
  • FDG-PET
  • Temporal lobe epilepsy
  • Wada memory test

Cite this

Seung Bong Hong, B. H., Suk Young Roh, Y. R., Kim, S. E., & Dae Won Seo, W. S. (2000). Correlation of temporal lobe glucose metabolism with the Wada memory test. Epilepsia, 41(12), 1554-1559. https://doi.org/10.1111/j.1499-1654.2000.001554.x