Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women

Soo Lim, Min Seon Kim, Kyong Soo Park, Jong Ho Lee, Geun Hee An, Mi Ja Yim, Jihyn Song, Youngmi Kim Pak, Hong Kyu Lee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hyperhomocysteinemia is an independent risk factor of cardiovascular disease and associated with insulin resistance, although their causal relationship remains unclear. A previous report has shown that high concentration of homocysteine damages mitochondrial gene expression, function and structure. As we found recently, the mitochondrial DNA (mtDNA) contents are inversely correlated with insulin resistance parameters. Thus there is possibility that plasma total homocysteine (tHcy) level is somewhat correlated with mtDNA content. Sixty healthy women (mean age 40.3±20.9 yr, range 18-78 yr) were recruited to investigate the correlation of plasma tHcy level and mtDNA content in peripheral blood. A significant negative correlation was found between plasma tHcy levels and mtDNA content (r=-0.507, P<0.01). Plasma tHcy and mtDNA content have an independent effect on each other and on insulin resistance (HOMA-insulin resistance (IR) score) respectively in multiple regression model. Plasma tHcy showed positive correlations with age (r=0.407), W/H ratio (r=0.370), total cholesterol (r=0.338), LDL-cholesterol (r=0.317) and insulin resistance (HOMA-IR score) (r=0.261); and a negative correlation with folate (r=-0.273). MtDNA content showed negative correlations with age (r=-0.407), BMI (r=-0.440), W/H ratio (r=-0.659), SBP (r=-0.350), total cholesterol (r=-0.340), triglyceride (r=-0.376), LDL-cholesterol (r=-0.349), fasting plasma insulin (r=-0.483), and insulin resistance (HOMA-IR score) (r=-0.423); and a positive correlation with folate (r=0.299). In this study, there was a significant inverse correlation between plasma tHcy level and mtDNA content. Further study will be warranted to elucidate the mechanism by which two factors are associated.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalAtherosclerosis
Volume158
Issue number2
DOIs
StatePublished - 1 Jan 2001

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Homocysteine
Mitochondrial DNA
Insulin Resistance
Folic Acid
LDL Cholesterol
Cholesterol
Hyperhomocysteinemia
Mitochondrial Genes
Fasting
Triglycerides
Cardiovascular Diseases
Insulin
Gene Expression

Keywords

  • Homeostasis model assessment (HOMA)
  • Homocysteine
  • Insulin resistance
  • Mitochondrial DNA (mtDNA) content

Cite this

Lim, Soo ; Seon Kim, Min ; Park, Kyong Soo ; Ho Lee, Jong ; Hee An, Geun ; Ja Yim, Mi ; Song, Jihyn ; Kim Pak, Youngmi ; Kyu Lee, Hong. / Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women. In: Atherosclerosis. 2001 ; Vol. 158, No. 2. pp. 399-405.
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title = "Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women",
abstract = "Hyperhomocysteinemia is an independent risk factor of cardiovascular disease and associated with insulin resistance, although their causal relationship remains unclear. A previous report has shown that high concentration of homocysteine damages mitochondrial gene expression, function and structure. As we found recently, the mitochondrial DNA (mtDNA) contents are inversely correlated with insulin resistance parameters. Thus there is possibility that plasma total homocysteine (tHcy) level is somewhat correlated with mtDNA content. Sixty healthy women (mean age 40.3±20.9 yr, range 18-78 yr) were recruited to investigate the correlation of plasma tHcy level and mtDNA content in peripheral blood. A significant negative correlation was found between plasma tHcy levels and mtDNA content (r=-0.507, P<0.01). Plasma tHcy and mtDNA content have an independent effect on each other and on insulin resistance (HOMA-insulin resistance (IR) score) respectively in multiple regression model. Plasma tHcy showed positive correlations with age (r=0.407), W/H ratio (r=0.370), total cholesterol (r=0.338), LDL-cholesterol (r=0.317) and insulin resistance (HOMA-IR score) (r=0.261); and a negative correlation with folate (r=-0.273). MtDNA content showed negative correlations with age (r=-0.407), BMI (r=-0.440), W/H ratio (r=-0.659), SBP (r=-0.350), total cholesterol (r=-0.340), triglyceride (r=-0.376), LDL-cholesterol (r=-0.349), fasting plasma insulin (r=-0.483), and insulin resistance (HOMA-IR score) (r=-0.423); and a positive correlation with folate (r=0.299). In this study, there was a significant inverse correlation between plasma tHcy level and mtDNA content. Further study will be warranted to elucidate the mechanism by which two factors are associated.",
keywords = "Homeostasis model assessment (HOMA), Homocysteine, Insulin resistance, Mitochondrial DNA (mtDNA) content",
author = "Soo Lim and {Seon Kim}, Min and Park, {Kyong Soo} and {Ho Lee}, Jong and {Hee An}, Geun and {Ja Yim}, Mi and Jihyn Song and {Kim Pak}, Youngmi and {Kyu Lee}, Hong",
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Lim, S, Seon Kim, M, Park, KS, Ho Lee, J, Hee An, G, Ja Yim, M, Song, J, Kim Pak, Y & Kyu Lee, H 2001, 'Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women', Atherosclerosis, vol. 158, no. 2, pp. 399-405. https://doi.org/10.1016/S0021-9150(01)00436-1

Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women. / Lim, Soo; Seon Kim, Min; Park, Kyong Soo; Ho Lee, Jong; Hee An, Geun; Ja Yim, Mi; Song, Jihyn; Kim Pak, Youngmi; Kyu Lee, Hong.

In: Atherosclerosis, Vol. 158, No. 2, 01.01.2001, p. 399-405.

Research output: Contribution to journalArticle

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T1 - Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women

AU - Lim, Soo

AU - Seon Kim, Min

AU - Park, Kyong Soo

AU - Ho Lee, Jong

AU - Hee An, Geun

AU - Ja Yim, Mi

AU - Song, Jihyn

AU - Kim Pak, Youngmi

AU - Kyu Lee, Hong

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AB - Hyperhomocysteinemia is an independent risk factor of cardiovascular disease and associated with insulin resistance, although their causal relationship remains unclear. A previous report has shown that high concentration of homocysteine damages mitochondrial gene expression, function and structure. As we found recently, the mitochondrial DNA (mtDNA) contents are inversely correlated with insulin resistance parameters. Thus there is possibility that plasma total homocysteine (tHcy) level is somewhat correlated with mtDNA content. Sixty healthy women (mean age 40.3±20.9 yr, range 18-78 yr) were recruited to investigate the correlation of plasma tHcy level and mtDNA content in peripheral blood. A significant negative correlation was found between plasma tHcy levels and mtDNA content (r=-0.507, P<0.01). Plasma tHcy and mtDNA content have an independent effect on each other and on insulin resistance (HOMA-insulin resistance (IR) score) respectively in multiple regression model. Plasma tHcy showed positive correlations with age (r=0.407), W/H ratio (r=0.370), total cholesterol (r=0.338), LDL-cholesterol (r=0.317) and insulin resistance (HOMA-IR score) (r=0.261); and a negative correlation with folate (r=-0.273). MtDNA content showed negative correlations with age (r=-0.407), BMI (r=-0.440), W/H ratio (r=-0.659), SBP (r=-0.350), total cholesterol (r=-0.340), triglyceride (r=-0.376), LDL-cholesterol (r=-0.349), fasting plasma insulin (r=-0.483), and insulin resistance (HOMA-IR score) (r=-0.423); and a positive correlation with folate (r=0.299). In this study, there was a significant inverse correlation between plasma tHcy level and mtDNA content. Further study will be warranted to elucidate the mechanism by which two factors are associated.

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