Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress

Bjarne Linde Nørgaard, Jonathon Leipsic, Bon Kwon Koo, Christopher K. Zarins, Jesper Møller Jensen, Niels Peter Sand, Charles A. Taylor

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Fractional flow reserve (FFR) measured during invasive coronary angiography is an independent prognosticator in patients with coronary artery disease and the gold standard for decision making in coronary revascularization. The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFRCT) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.

Original languageEnglish
Article number2
Pages (from-to)1-12
Number of pages12
JournalCurrent Cardiovascular Imaging Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Jan 2016

Fingerprint

Patient Simulation
Atherosclerotic Plaques
Hydrodynamics
Coronary Angiography
Coronary Artery Disease
Decision Making
Hemodynamics
Tomography
Blood Pressure
Technology
Pressure
Computed Tomography Angiography
Therapeutics
Datasets

Keywords

  • Atherosclerosis
  • Axial plaque stress
  • Computational fluid dynamics
  • Coronary artery disease
  • Coronary computed tomography angiography
  • Coronary plaque
  • Fractional flow reserve
  • Invasive coronary angiography
  • Myocardial ischemia
  • Noninvasive cardiac imaging
  • Noninvasive diagnostic testing
  • Prognosis
  • Wall shear stress

Cite this

Nørgaard, Bjarne Linde ; Leipsic, Jonathon ; Koo, Bon Kwon ; Zarins, Christopher K. ; Jensen, Jesper Møller ; Sand, Niels Peter ; Taylor, Charles A. / Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress. In: Current Cardiovascular Imaging Reports. 2016 ; Vol. 9, No. 1. pp. 1-12.
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keywords = "Atherosclerosis, Axial plaque stress, Computational fluid dynamics, Coronary artery disease, Coronary computed tomography angiography, Coronary plaque, Fractional flow reserve, Invasive coronary angiography, Myocardial ischemia, Noninvasive cardiac imaging, Noninvasive diagnostic testing, Prognosis, Wall shear stress",
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Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress. / Nørgaard, Bjarne Linde; Leipsic, Jonathon; Koo, Bon Kwon; Zarins, Christopher K.; Jensen, Jesper Møller; Sand, Niels Peter; Taylor, Charles A.

In: Current Cardiovascular Imaging Reports, Vol. 9, No. 1, 2, 01.01.2016, p. 1-12.

Research output: Contribution to journalReview article

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AU - Taylor, Charles A.

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