Computational modeling of effects of mechanical shaking on hemodynamics in hollow fibers

Jeong Chul Kim, Francesco Garzotto, Dinna N. Cruz, Anna Clementi, Federico Nalesso, Ji Hyun Kim, Eungtaek Kang, Hee Chan Kim, Claudio Ronco

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Introduction: Blood-membrane interaction during hemodialysis develops a secondary protein layer on the dialysis membrane surface, resulting in reduction of hemodialyzer performance. Wall shear stress at the surface of the hollow-fiber membrane is one of the determinant factors able to influence dialysis efficiency. Shaking of hemodialyzer during treatment could increase the wall shear stress of the membrane, which could enhance hemodialyzer performance. Methods: In this study, hemodynamic changes in hollow fibers were analyzed using computational fluid dynamics software for various shaking conditions of hemodialyzer (longitudinal, transverse, rotational motions). Results: Longitudinal motion induced reverse flow, while transverse motion induced symmetric swirling inside the hollow fiber. During rotational motions, nonuniform vortices were developed according to the rotational radius of the hollow fiber. These changes in flow pathlines induced by different shaking profiles increased the relative motion of blood, transmembrane pressure, and wall shear stress on dialysis membrane surfaces. Both longitudinal and transverse shaking profiles showed a linear relationship between shaking velocity (the product of amplitude and frequency) and wall shear stress. Conclusion: Performance of hemodialyzer can be enhanced with simple mechanical shaking motions, and optimal shaking profiles for clinical application can be investigated and predicted with the computational fluid dynamics model proposed in this study.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalInternational Journal of Artificial Organs
Volume35
Issue number4
DOIs
StatePublished - 5 Jul 2012

Fingerprint

Hemodialyzers
Artificial Kidneys
Hemodynamics
Shear stress
Dialysis membranes
Fibers
Membranes
Dialysis
Hydrodynamics
Computational fluid dynamics
Blood pressure
Dynamic models
Vortex flow
Blood
Renal Dialysis
Proteins
Software
Blood Pressure

Keywords

  • Computational fluid dynamics
  • Concentration polarization
  • Dialysis adequacy
  • Hemodiafiltration
  • Mechanical stress
  • Membrane fouling
  • Shaking

Cite this

Kim, J. C., Garzotto, F., Cruz, D. N., Clementi, A., Nalesso, F., Kim, J. H., ... Ronco, C. (2012). Computational modeling of effects of mechanical shaking on hemodynamics in hollow fibers. International Journal of Artificial Organs, 35(4), 301-307. https://doi.org/10.5301/ijao.5000094
Kim, Jeong Chul ; Garzotto, Francesco ; Cruz, Dinna N. ; Clementi, Anna ; Nalesso, Federico ; Kim, Ji Hyun ; Kang, Eungtaek ; Kim, Hee Chan ; Ronco, Claudio. / Computational modeling of effects of mechanical shaking on hemodynamics in hollow fibers. In: International Journal of Artificial Organs. 2012 ; Vol. 35, No. 4. pp. 301-307.
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abstract = "Introduction: Blood-membrane interaction during hemodialysis develops a secondary protein layer on the dialysis membrane surface, resulting in reduction of hemodialyzer performance. Wall shear stress at the surface of the hollow-fiber membrane is one of the determinant factors able to influence dialysis efficiency. Shaking of hemodialyzer during treatment could increase the wall shear stress of the membrane, which could enhance hemodialyzer performance. Methods: In this study, hemodynamic changes in hollow fibers were analyzed using computational fluid dynamics software for various shaking conditions of hemodialyzer (longitudinal, transverse, rotational motions). Results: Longitudinal motion induced reverse flow, while transverse motion induced symmetric swirling inside the hollow fiber. During rotational motions, nonuniform vortices were developed according to the rotational radius of the hollow fiber. These changes in flow pathlines induced by different shaking profiles increased the relative motion of blood, transmembrane pressure, and wall shear stress on dialysis membrane surfaces. Both longitudinal and transverse shaking profiles showed a linear relationship between shaking velocity (the product of amplitude and frequency) and wall shear stress. Conclusion: Performance of hemodialyzer can be enhanced with simple mechanical shaking motions, and optimal shaking profiles for clinical application can be investigated and predicted with the computational fluid dynamics model proposed in this study.",
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Kim, JC, Garzotto, F, Cruz, DN, Clementi, A, Nalesso, F, Kim, JH, Kang, E, Kim, HC & Ronco, C 2012, 'Computational modeling of effects of mechanical shaking on hemodynamics in hollow fibers', International Journal of Artificial Organs, vol. 35, no. 4, pp. 301-307. https://doi.org/10.5301/ijao.5000094

Computational modeling of effects of mechanical shaking on hemodynamics in hollow fibers. / Kim, Jeong Chul; Garzotto, Francesco; Cruz, Dinna N.; Clementi, Anna; Nalesso, Federico; Kim, Ji Hyun; Kang, Eungtaek; Kim, Hee Chan; Ronco, Claudio.

In: International Journal of Artificial Organs, Vol. 35, No. 4, 05.07.2012, p. 301-307.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Computational modeling of effects of mechanical shaking on hemodynamics in hollow fibers

AU - Kim, Jeong Chul

AU - Garzotto, Francesco

AU - Cruz, Dinna N.

AU - Clementi, Anna

AU - Nalesso, Federico

AU - Kim, Ji Hyun

AU - Kang, Eungtaek

AU - Kim, Hee Chan

AU - Ronco, Claudio

PY - 2012/7/5

Y1 - 2012/7/5

N2 - Introduction: Blood-membrane interaction during hemodialysis develops a secondary protein layer on the dialysis membrane surface, resulting in reduction of hemodialyzer performance. Wall shear stress at the surface of the hollow-fiber membrane is one of the determinant factors able to influence dialysis efficiency. Shaking of hemodialyzer during treatment could increase the wall shear stress of the membrane, which could enhance hemodialyzer performance. Methods: In this study, hemodynamic changes in hollow fibers were analyzed using computational fluid dynamics software for various shaking conditions of hemodialyzer (longitudinal, transverse, rotational motions). Results: Longitudinal motion induced reverse flow, while transverse motion induced symmetric swirling inside the hollow fiber. During rotational motions, nonuniform vortices were developed according to the rotational radius of the hollow fiber. These changes in flow pathlines induced by different shaking profiles increased the relative motion of blood, transmembrane pressure, and wall shear stress on dialysis membrane surfaces. Both longitudinal and transverse shaking profiles showed a linear relationship between shaking velocity (the product of amplitude and frequency) and wall shear stress. Conclusion: Performance of hemodialyzer can be enhanced with simple mechanical shaking motions, and optimal shaking profiles for clinical application can be investigated and predicted with the computational fluid dynamics model proposed in this study.

AB - Introduction: Blood-membrane interaction during hemodialysis develops a secondary protein layer on the dialysis membrane surface, resulting in reduction of hemodialyzer performance. Wall shear stress at the surface of the hollow-fiber membrane is one of the determinant factors able to influence dialysis efficiency. Shaking of hemodialyzer during treatment could increase the wall shear stress of the membrane, which could enhance hemodialyzer performance. Methods: In this study, hemodynamic changes in hollow fibers were analyzed using computational fluid dynamics software for various shaking conditions of hemodialyzer (longitudinal, transverse, rotational motions). Results: Longitudinal motion induced reverse flow, while transverse motion induced symmetric swirling inside the hollow fiber. During rotational motions, nonuniform vortices were developed according to the rotational radius of the hollow fiber. These changes in flow pathlines induced by different shaking profiles increased the relative motion of blood, transmembrane pressure, and wall shear stress on dialysis membrane surfaces. Both longitudinal and transverse shaking profiles showed a linear relationship between shaking velocity (the product of amplitude and frequency) and wall shear stress. Conclusion: Performance of hemodialyzer can be enhanced with simple mechanical shaking motions, and optimal shaking profiles for clinical application can be investigated and predicted with the computational fluid dynamics model proposed in this study.

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KW - Concentration polarization

KW - Dialysis adequacy

KW - Hemodiafiltration

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KW - Membrane fouling

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DO - 10.5301/ijao.5000094

M3 - Article

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EP - 307

JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

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