Comparison of Two-Year Outcomes of Acute Myocardial Infarction Caused by Coronary Artery Spasm Versus that Caused by Coronary Atherosclerosis

Ju Yeol Baek, Byoung Geol Choi, Seung Woon Rha, Cheol Ung Choi, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Tae Hoon Ahn, Kiyuk Chang, Shung Chull Chae, Seung Ho Hur, Kwang Soo Cha, In Ho Choi, Hyo Soo Kim, Hyeon Cheol Gwon, Young Jo Kim, Seok Kyu Oh, Jei Keon Chae, In Whan Seong, Kyung Kook HwangChong Jin Kim, Jung Han Yoon, Jin Yong Hwang, Doo Il Kim, Seung Jae Joo, Myung ho Jeong

Research output: Contribution to journalArticle

Abstract

The study compared the 2-year outcomes of patients diagnosed with acute myocardial infarction (AMI) triggered by coronary artery atherosclerosis and AMI caused by coronary artery spasm. A total of 36,797 patients in the Korea AMI Registry were grouped into 2 categories—(1) AMI due to coronary artery spasm without stenotic lesion (CAS-AMI, n = 484); and (2) AMI induced by coronary artery atherosclerosis (CAA-AMI, n = 36,313). The major clinical outcomes of the 2 groups were compared over a 2-year clinical follow-up period. Major adverse cardiac events (MACE) were defined as the composite of total death, nonfatal myocardial infarction, and repeat revascularization. The incidence of MACE (7.1% vs 11.1%; p = 0.007) and repeat revascularization (0.4% vs 4.2%; p <0.001) in the CAS-AMI group were significantly lower than in the CAA-AMI group at 2 years. However, the incidence of total death and nonfatal myocardial infarction was similar in both the groups. Aborted cardiac arrest was strongly associated with 2-year mortality in the CAS-AMI group (hazard ratios 13.5, 95% confidence interval 5.34 to 34.15, p <0.001) The incidence of MACE in CAS-AMI patients was significantly lower than in the CAA-AMI group of patients up to 2 years due to the relatively lower rate of repeat revascularization in CAS-AMI patients. However, the incidence of total death or nonfatal myocardial infarction in CAS-AMI patients was not different from that of patients with CAA-AMI.

Original languageEnglish
Pages (from-to)1493-1500
Number of pages8
JournalAmerican Journal of Cardiology
Volume124
Issue number10
DOIs
StatePublished - 15 Nov 2019

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Spasm
Coronary Artery Disease
Coronary Vessels
Myocardial Infarction
Incidence
Korea
Heart Arrest

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Baek, Ju Yeol ; Choi, Byoung Geol ; Rha, Seung Woon ; Choi, Cheol Ung ; Park, Chang Gyu ; Seo, Hong Seog ; Oh, Dong Joo ; Ahn, Tae Hoon ; Chang, Kiyuk ; Chae, Shung Chull ; Hur, Seung Ho ; Cha, Kwang Soo ; Choi, In Ho ; Kim, Hyo Soo ; Gwon, Hyeon Cheol ; Kim, Young Jo ; Oh, Seok Kyu ; Chae, Jei Keon ; Seong, In Whan ; Hwang, Kyung Kook ; Kim, Chong Jin ; Yoon, Jung Han ; Hwang, Jin Yong ; Kim, Doo Il ; Joo, Seung Jae ; Jeong, Myung ho. / Comparison of Two-Year Outcomes of Acute Myocardial Infarction Caused by Coronary Artery Spasm Versus that Caused by Coronary Atherosclerosis. In: American Journal of Cardiology. 2019 ; Vol. 124, No. 10. pp. 1493-1500.
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abstract = "The study compared the 2-year outcomes of patients diagnosed with acute myocardial infarction (AMI) triggered by coronary artery atherosclerosis and AMI caused by coronary artery spasm. A total of 36,797 patients in the Korea AMI Registry were grouped into 2 categories—(1) AMI due to coronary artery spasm without stenotic lesion (CAS-AMI, n = 484); and (2) AMI induced by coronary artery atherosclerosis (CAA-AMI, n = 36,313). The major clinical outcomes of the 2 groups were compared over a 2-year clinical follow-up period. Major adverse cardiac events (MACE) were defined as the composite of total death, nonfatal myocardial infarction, and repeat revascularization. The incidence of MACE (7.1{\%} vs 11.1{\%}; p = 0.007) and repeat revascularization (0.4{\%} vs 4.2{\%}; p <0.001) in the CAS-AMI group were significantly lower than in the CAA-AMI group at 2 years. However, the incidence of total death and nonfatal myocardial infarction was similar in both the groups. Aborted cardiac arrest was strongly associated with 2-year mortality in the CAS-AMI group (hazard ratios 13.5, 95{\%} confidence interval 5.34 to 34.15, p <0.001) The incidence of MACE in CAS-AMI patients was significantly lower than in the CAA-AMI group of patients up to 2 years due to the relatively lower rate of repeat revascularization in CAS-AMI patients. However, the incidence of total death or nonfatal myocardial infarction in CAS-AMI patients was not different from that of patients with CAA-AMI.",
author = "Baek, {Ju Yeol} and Choi, {Byoung Geol} and Rha, {Seung Woon} and Choi, {Cheol Ung} and Park, {Chang Gyu} and Seo, {Hong Seog} and Oh, {Dong Joo} and Ahn, {Tae Hoon} and Kiyuk Chang and Chae, {Shung Chull} and Hur, {Seung Ho} and Cha, {Kwang Soo} and Choi, {In Ho} and Kim, {Hyo Soo} and Gwon, {Hyeon Cheol} and Kim, {Young Jo} and Oh, {Seok Kyu} and Chae, {Jei Keon} and Seong, {In Whan} and Hwang, {Kyung Kook} and Kim, {Chong Jin} and Yoon, {Jung Han} and Hwang, {Jin Yong} and Kim, {Doo Il} and Joo, {Seung Jae} and Jeong, {Myung ho}",
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journal = "American Journal of Cardiology",
issn = "0002-9149",
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Baek, JY, Choi, BG, Rha, SW, Choi, CU, Park, CG, Seo, HS, Oh, DJ, Ahn, TH, Chang, K, Chae, SC, Hur, SH, Cha, KS, Choi, IH, Kim, HS, Gwon, HC, Kim, YJ, Oh, SK, Chae, JK, Seong, IW, Hwang, KK, Kim, CJ, Yoon, JH, Hwang, JY, Kim, DI, Joo, SJ & Jeong, MH 2019, 'Comparison of Two-Year Outcomes of Acute Myocardial Infarction Caused by Coronary Artery Spasm Versus that Caused by Coronary Atherosclerosis', American Journal of Cardiology, vol. 124, no. 10, pp. 1493-1500. https://doi.org/10.1016/j.amjcard.2019.08.019

Comparison of Two-Year Outcomes of Acute Myocardial Infarction Caused by Coronary Artery Spasm Versus that Caused by Coronary Atherosclerosis. / Baek, Ju Yeol; Choi, Byoung Geol; Rha, Seung Woon; Choi, Cheol Ung; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Ahn, Tae Hoon; Chang, Kiyuk; Chae, Shung Chull; Hur, Seung Ho; Cha, Kwang Soo; Choi, In Ho; Kim, Hyo Soo; Gwon, Hyeon Cheol; Kim, Young Jo; Oh, Seok Kyu; Chae, Jei Keon; Seong, In Whan; Hwang, Kyung Kook; Kim, Chong Jin; Yoon, Jung Han; Hwang, Jin Yong; Kim, Doo Il; Joo, Seung Jae; Jeong, Myung ho.

In: American Journal of Cardiology, Vol. 124, No. 10, 15.11.2019, p. 1493-1500.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of Two-Year Outcomes of Acute Myocardial Infarction Caused by Coronary Artery Spasm Versus that Caused by Coronary Atherosclerosis

AU - Baek, Ju Yeol

AU - Choi, Byoung Geol

AU - Rha, Seung Woon

AU - Choi, Cheol Ung

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

AU - Ahn, Tae Hoon

AU - Chang, Kiyuk

AU - Chae, Shung Chull

AU - Hur, Seung Ho

AU - Cha, Kwang Soo

AU - Choi, In Ho

AU - Kim, Hyo Soo

AU - Gwon, Hyeon Cheol

AU - Kim, Young Jo

AU - Oh, Seok Kyu

AU - Chae, Jei Keon

AU - Seong, In Whan

AU - Hwang, Kyung Kook

AU - Kim, Chong Jin

AU - Yoon, Jung Han

AU - Hwang, Jin Yong

AU - Kim, Doo Il

AU - Joo, Seung Jae

AU - Jeong, Myung ho

PY - 2019/11/15

Y1 - 2019/11/15

N2 - The study compared the 2-year outcomes of patients diagnosed with acute myocardial infarction (AMI) triggered by coronary artery atherosclerosis and AMI caused by coronary artery spasm. A total of 36,797 patients in the Korea AMI Registry were grouped into 2 categories—(1) AMI due to coronary artery spasm without stenotic lesion (CAS-AMI, n = 484); and (2) AMI induced by coronary artery atherosclerosis (CAA-AMI, n = 36,313). The major clinical outcomes of the 2 groups were compared over a 2-year clinical follow-up period. Major adverse cardiac events (MACE) were defined as the composite of total death, nonfatal myocardial infarction, and repeat revascularization. The incidence of MACE (7.1% vs 11.1%; p = 0.007) and repeat revascularization (0.4% vs 4.2%; p <0.001) in the CAS-AMI group were significantly lower than in the CAA-AMI group at 2 years. However, the incidence of total death and nonfatal myocardial infarction was similar in both the groups. Aborted cardiac arrest was strongly associated with 2-year mortality in the CAS-AMI group (hazard ratios 13.5, 95% confidence interval 5.34 to 34.15, p <0.001) The incidence of MACE in CAS-AMI patients was significantly lower than in the CAA-AMI group of patients up to 2 years due to the relatively lower rate of repeat revascularization in CAS-AMI patients. However, the incidence of total death or nonfatal myocardial infarction in CAS-AMI patients was not different from that of patients with CAA-AMI.

AB - The study compared the 2-year outcomes of patients diagnosed with acute myocardial infarction (AMI) triggered by coronary artery atherosclerosis and AMI caused by coronary artery spasm. A total of 36,797 patients in the Korea AMI Registry were grouped into 2 categories—(1) AMI due to coronary artery spasm without stenotic lesion (CAS-AMI, n = 484); and (2) AMI induced by coronary artery atherosclerosis (CAA-AMI, n = 36,313). The major clinical outcomes of the 2 groups were compared over a 2-year clinical follow-up period. Major adverse cardiac events (MACE) were defined as the composite of total death, nonfatal myocardial infarction, and repeat revascularization. The incidence of MACE (7.1% vs 11.1%; p = 0.007) and repeat revascularization (0.4% vs 4.2%; p <0.001) in the CAS-AMI group were significantly lower than in the CAA-AMI group at 2 years. However, the incidence of total death and nonfatal myocardial infarction was similar in both the groups. Aborted cardiac arrest was strongly associated with 2-year mortality in the CAS-AMI group (hazard ratios 13.5, 95% confidence interval 5.34 to 34.15, p <0.001) The incidence of MACE in CAS-AMI patients was significantly lower than in the CAA-AMI group of patients up to 2 years due to the relatively lower rate of repeat revascularization in CAS-AMI patients. However, the incidence of total death or nonfatal myocardial infarction in CAS-AMI patients was not different from that of patients with CAA-AMI.

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