Comparison of the diagnostic performances of core needle biopsy in myxoid versus non-myxoid tumors

Himanshu Rohela, Cheol Lee, Hye Jin Yoo, Han-Soo Kim, Yongsung Kim, Hwan-Seong Cho, Ilkyu Han

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Despite the overall diagnostic utility of core needle biopsy (CNB) comparable to incisional biopsy, increased diagnostic errors have been suggested of CNB for myxoid soft tissue tumors. This study compared the diagnostic performance of CNB between myxoid and non-myxoid soft tissue tumors. Methods: 369 patients who underwent ultrasound-guided CNB prior to resection for soft tissue tumors were classified into two groups according to resection pathology; myxoid group (n = 75) and non-myxoid group (n = 294). One-hundred and ninety-three patients were male and the median age of the patients was 40 years. Two-hundred and sixty-three tumors were malignant. Results: CNB correctly diagnosed malignancy in 84% (58 of 69) for the myxoid group and 95% (184 of 194) for the non-myxoid group. For diagnosing histologic grade of soft tissue sarcoma, CNB correctly identified high grade in 78% (18 of 23) for the myxoid group and 74% (94 of 128) for the non-myxoid group. Correct diagnosis rate of histological type was significantly lower in the myxoid group (63% [47 of 75] in the myxoid group and 83% [242 of 294] in the non-myxoid group, p = 0.013). Conclusion: Our study suggests that CNB is useful for myxoid soft tissue tumors of the extremity, with regard to diagnosing malignancy and histologic grade. However, CNB was less useful for identifying histologic subtype in myxoid tumors than in non-myxoid tumors.

Original languageEnglish
Pages (from-to)1293-1298
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume45
Issue number7
DOIs
StatePublished - 1 Jul 2019

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Large-Core Needle Biopsy
Neoplasms
Diagnostic Errors
Sarcoma
Extremities
Pathology
Biopsy

Keywords

  • Core needle biopsy
  • Diagnostic accuracy
  • Histologic subtype
  • Myxoid tumor
  • Soft tissue sarcoma

Cite this

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title = "Comparison of the diagnostic performances of core needle biopsy in myxoid versus non-myxoid tumors",
abstract = "Background: Despite the overall diagnostic utility of core needle biopsy (CNB) comparable to incisional biopsy, increased diagnostic errors have been suggested of CNB for myxoid soft tissue tumors. This study compared the diagnostic performance of CNB between myxoid and non-myxoid soft tissue tumors. Methods: 369 patients who underwent ultrasound-guided CNB prior to resection for soft tissue tumors were classified into two groups according to resection pathology; myxoid group (n = 75) and non-myxoid group (n = 294). One-hundred and ninety-three patients were male and the median age of the patients was 40 years. Two-hundred and sixty-three tumors were malignant. Results: CNB correctly diagnosed malignancy in 84{\%} (58 of 69) for the myxoid group and 95{\%} (184 of 194) for the non-myxoid group. For diagnosing histologic grade of soft tissue sarcoma, CNB correctly identified high grade in 78{\%} (18 of 23) for the myxoid group and 74{\%} (94 of 128) for the non-myxoid group. Correct diagnosis rate of histological type was significantly lower in the myxoid group (63{\%} [47 of 75] in the myxoid group and 83{\%} [242 of 294] in the non-myxoid group, p = 0.013). Conclusion: Our study suggests that CNB is useful for myxoid soft tissue tumors of the extremity, with regard to diagnosing malignancy and histologic grade. However, CNB was less useful for identifying histologic subtype in myxoid tumors than in non-myxoid tumors.",
keywords = "Core needle biopsy, Diagnostic accuracy, Histologic subtype, Myxoid tumor, Soft tissue sarcoma",
author = "Himanshu Rohela and Cheol Lee and Yoo, {Hye Jin} and Han-Soo Kim and Yongsung Kim and Hwan-Seong Cho and Ilkyu Han",
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Comparison of the diagnostic performances of core needle biopsy in myxoid versus non-myxoid tumors. / Rohela, Himanshu; Lee, Cheol; Yoo, Hye Jin; Kim, Han-Soo; Kim, Yongsung; Cho, Hwan-Seong; Han, Ilkyu.

In: European Journal of Surgical Oncology, Vol. 45, No. 7, 01.07.2019, p. 1293-1298.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Comparison of the diagnostic performances of core needle biopsy in myxoid versus non-myxoid tumors

AU - Rohela, Himanshu

AU - Lee, Cheol

AU - Yoo, Hye Jin

AU - Kim, Han-Soo

AU - Kim, Yongsung

AU - Cho, Hwan-Seong

AU - Han, Ilkyu

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Despite the overall diagnostic utility of core needle biopsy (CNB) comparable to incisional biopsy, increased diagnostic errors have been suggested of CNB for myxoid soft tissue tumors. This study compared the diagnostic performance of CNB between myxoid and non-myxoid soft tissue tumors. Methods: 369 patients who underwent ultrasound-guided CNB prior to resection for soft tissue tumors were classified into two groups according to resection pathology; myxoid group (n = 75) and non-myxoid group (n = 294). One-hundred and ninety-three patients were male and the median age of the patients was 40 years. Two-hundred and sixty-three tumors were malignant. Results: CNB correctly diagnosed malignancy in 84% (58 of 69) for the myxoid group and 95% (184 of 194) for the non-myxoid group. For diagnosing histologic grade of soft tissue sarcoma, CNB correctly identified high grade in 78% (18 of 23) for the myxoid group and 74% (94 of 128) for the non-myxoid group. Correct diagnosis rate of histological type was significantly lower in the myxoid group (63% [47 of 75] in the myxoid group and 83% [242 of 294] in the non-myxoid group, p = 0.013). Conclusion: Our study suggests that CNB is useful for myxoid soft tissue tumors of the extremity, with regard to diagnosing malignancy and histologic grade. However, CNB was less useful for identifying histologic subtype in myxoid tumors than in non-myxoid tumors.

AB - Background: Despite the overall diagnostic utility of core needle biopsy (CNB) comparable to incisional biopsy, increased diagnostic errors have been suggested of CNB for myxoid soft tissue tumors. This study compared the diagnostic performance of CNB between myxoid and non-myxoid soft tissue tumors. Methods: 369 patients who underwent ultrasound-guided CNB prior to resection for soft tissue tumors were classified into two groups according to resection pathology; myxoid group (n = 75) and non-myxoid group (n = 294). One-hundred and ninety-three patients were male and the median age of the patients was 40 years. Two-hundred and sixty-three tumors were malignant. Results: CNB correctly diagnosed malignancy in 84% (58 of 69) for the myxoid group and 95% (184 of 194) for the non-myxoid group. For diagnosing histologic grade of soft tissue sarcoma, CNB correctly identified high grade in 78% (18 of 23) for the myxoid group and 74% (94 of 128) for the non-myxoid group. Correct diagnosis rate of histological type was significantly lower in the myxoid group (63% [47 of 75] in the myxoid group and 83% [242 of 294] in the non-myxoid group, p = 0.013). Conclusion: Our study suggests that CNB is useful for myxoid soft tissue tumors of the extremity, with regard to diagnosing malignancy and histologic grade. However, CNB was less useful for identifying histologic subtype in myxoid tumors than in non-myxoid tumors.

KW - Core needle biopsy

KW - Diagnostic accuracy

KW - Histologic subtype

KW - Myxoid tumor

KW - Soft tissue sarcoma

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DO - 10.1016/j.ejso.2019.05.001

M3 - Article

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JF - European Journal of Surgical Oncology

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