Comparison of the diagnostic performances of core needle biopsy in myxoid versus non-myxoid tumors

Himanshu Rohela, Cheol Lee, Hye Jin Yoo, Han Soo Kim, Yongsung Kim, Hwan Seong Cho, Ilkyu Han

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Background: Despite the overall diagnostic utility of core needle biopsy (CNB) comparable to incisional biopsy, increased diagnostic errors have been suggested of CNB for myxoid soft tissue tumors. This study compared the diagnostic performance of CNB between myxoid and non-myxoid soft tissue tumors. Methods: 369 patients who underwent ultrasound-guided CNB prior to resection for soft tissue tumors were classified into two groups according to resection pathology; myxoid group (n = 75) and non-myxoid group (n = 294). One-hundred and ninety-three patients were male and the median age of the patients was 40 years. Two-hundred and sixty-three tumors were malignant. Results: CNB correctly diagnosed malignancy in 84% (58 of 69) for the myxoid group and 95% (184 of 194) for the non-myxoid group. For diagnosing histologic grade of soft tissue sarcoma, CNB correctly identified high grade in 78% (18 of 23) for the myxoid group and 74% (94 of 128) for the non-myxoid group. Correct diagnosis rate of histological type was significantly lower in the myxoid group (63% [47 of 75] in the myxoid group and 83% [242 of 294] in the non-myxoid group, p = 0.013). Conclusion: Our study suggests that CNB is useful for myxoid soft tissue tumors of the extremity, with regard to diagnosing malignancy and histologic grade. However, CNB was less useful for identifying histologic subtype in myxoid tumors than in non-myxoid tumors.

Original languageEnglish
Pages (from-to)1293-1298
Number of pages6
JournalEuropean Journal of Surgical Oncology
Issue number7
StatePublished - Jul 2019


  • Core needle biopsy
  • Diagnostic accuracy
  • Histologic subtype
  • Myxoid tumor
  • Soft tissue sarcoma

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