Comparison of radical prostatectomy and external beam radiotherapy in high-risk prostate cancer

Seok Joo Chun, Jin Ho Kim, Ja Hyeon Ku, Cheol Kwak, Eun Sik Lee, Suzy Kim

Research output: Contribution to journalArticlepeer-review


Purpose: We evaluated clinical outcomes of high-risk prostate cancer patients receiving external beam radiotherapy (EBRT) or radical prostatectomy (RP). Materials and Methods: Patients were classified as high-risk prostate cancer and received definitive treatment between 2005 and 2015. Patients with previous pelvic radiotherapy, positive lymph node or distant metastasis were excluded. The primary outcomes were prostate cancer-specific survival (PCSS) and distant metastasis-free survival (DMFS). Results: Of 583 patients met the inclusion criteria (77 EBRT and 506 RP), the estimated 10-year PCSS was 97.0% in the RP and 95.9% in the EBRT (p = 0.770). No significant difference was seen in the DMFS (p = 0.540), whereas there was a trend in favor of RP over EBRT in overall survival (OS) (p = 0.068). Propensity score matching analysis with confounding variables was done, with 183 patients (66 EBRT and 117 RP) were included. No significant difference in DMFS, PCSS or OS was found. Conclusion: Our data demonstrated similar oncologic PCSS, OS, and DMFS outcomes between EBRT and RP patients.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalRadiation Oncology Journal
Issue number3
StatePublished - Sep 2021


  • Prostatectomy
  • Prostatic neoplasms
  • Radiotherapy


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