Comparison of localized retinal nerve fiber layer defects in highly myopic, myopic, and non-myopic patients with normal-tension glaucoma: A retrospective cross-sectional study

Joon Mo Kim, Ki Ho Park, Seon Jeong Kim, Hyo Ju Jang, Eun Noh, Mi Jeung Kim, Tae Woo Kim, Dong Myung Kim, Joseph Caprioli

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The purpose of this study was to evaluate the relationship between patterns of localized retinal nerve fiber layer (RNFL) defects and the degree of myopia in patients with normal-tension glaucoma (NTG). Methods. We retrospectively reviewed medical records of patients with high myopia (42 eyes; spherical equivalent [SE] < -6.0 diopters [D]), low to moderate myopia (93 eyes; SE -6.0D ∼ and -0.5D), and emmetropia (65 eyes; SE -0.5D ∼ +0.5D), all of which were diagnosed as having NTG with localized RNFL defects. On RNFL photographs, the proximity of the RNFL defect to the center of the fovea (angle I) and the sum of the angular width of the defects (angle II) were determined. The patterns of localized RNFL defects were then compared with respect to differences in angles I and II. Results: Angle I was significantly smaller in the high myopia group than in the low to moderate myopia group (p = 0.028) and the emmetropia group (p = 0.044), while angle II was significantly larger in the high myopia group compared with the low to moderate myopia group and the emmetropia group (p < 0.001, p = 0.007). Conclusions: Among subjects with NTG, localized RNFL defects are wider and closer to the fovea in eyes with high myopia than those with low to moderate myopia or emmetropia.

Original languageEnglish
Article number67
JournalBMC Ophthalmology
Volume13
Issue number1
DOIs
StatePublished - 12 Nov 2013

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Low Tension Glaucoma
Myopia
Nerve Fibers
Cross-Sectional Studies
Emmetropia
Medical Records

Keywords

  • Myopia
  • Normal-tension glaucoma
  • RNFL defect
  • Refractive error

Cite this

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title = "Comparison of localized retinal nerve fiber layer defects in highly myopic, myopic, and non-myopic patients with normal-tension glaucoma: A retrospective cross-sectional study",
abstract = "Background: The purpose of this study was to evaluate the relationship between patterns of localized retinal nerve fiber layer (RNFL) defects and the degree of myopia in patients with normal-tension glaucoma (NTG). Methods. We retrospectively reviewed medical records of patients with high myopia (42 eyes; spherical equivalent [SE] < -6.0 diopters [D]), low to moderate myopia (93 eyes; SE -6.0D ∼ and -0.5D), and emmetropia (65 eyes; SE -0.5D ∼ +0.5D), all of which were diagnosed as having NTG with localized RNFL defects. On RNFL photographs, the proximity of the RNFL defect to the center of the fovea (angle I) and the sum of the angular width of the defects (angle II) were determined. The patterns of localized RNFL defects were then compared with respect to differences in angles I and II. Results: Angle I was significantly smaller in the high myopia group than in the low to moderate myopia group (p = 0.028) and the emmetropia group (p = 0.044), while angle II was significantly larger in the high myopia group compared with the low to moderate myopia group and the emmetropia group (p < 0.001, p = 0.007). Conclusions: Among subjects with NTG, localized RNFL defects are wider and closer to the fovea in eyes with high myopia than those with low to moderate myopia or emmetropia.",
keywords = "Myopia, Normal-tension glaucoma, RNFL defect, Refractive error",
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month = "11",
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Comparison of localized retinal nerve fiber layer defects in highly myopic, myopic, and non-myopic patients with normal-tension glaucoma : A retrospective cross-sectional study. / Kim, Joon Mo; Park, Ki Ho; Kim, Seon Jeong; Jang, Hyo Ju; Noh, Eun; Kim, Mi Jeung; Kim, Tae Woo; Kim, Dong Myung; Caprioli, Joseph.

In: BMC Ophthalmology, Vol. 13, No. 1, 67, 12.11.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of localized retinal nerve fiber layer defects in highly myopic, myopic, and non-myopic patients with normal-tension glaucoma

T2 - A retrospective cross-sectional study

AU - Kim, Joon Mo

AU - Park, Ki Ho

AU - Kim, Seon Jeong

AU - Jang, Hyo Ju

AU - Noh, Eun

AU - Kim, Mi Jeung

AU - Kim, Tae Woo

AU - Kim, Dong Myung

AU - Caprioli, Joseph

PY - 2013/11/12

Y1 - 2013/11/12

N2 - Background: The purpose of this study was to evaluate the relationship between patterns of localized retinal nerve fiber layer (RNFL) defects and the degree of myopia in patients with normal-tension glaucoma (NTG). Methods. We retrospectively reviewed medical records of patients with high myopia (42 eyes; spherical equivalent [SE] < -6.0 diopters [D]), low to moderate myopia (93 eyes; SE -6.0D ∼ and -0.5D), and emmetropia (65 eyes; SE -0.5D ∼ +0.5D), all of which were diagnosed as having NTG with localized RNFL defects. On RNFL photographs, the proximity of the RNFL defect to the center of the fovea (angle I) and the sum of the angular width of the defects (angle II) were determined. The patterns of localized RNFL defects were then compared with respect to differences in angles I and II. Results: Angle I was significantly smaller in the high myopia group than in the low to moderate myopia group (p = 0.028) and the emmetropia group (p = 0.044), while angle II was significantly larger in the high myopia group compared with the low to moderate myopia group and the emmetropia group (p < 0.001, p = 0.007). Conclusions: Among subjects with NTG, localized RNFL defects are wider and closer to the fovea in eyes with high myopia than those with low to moderate myopia or emmetropia.

AB - Background: The purpose of this study was to evaluate the relationship between patterns of localized retinal nerve fiber layer (RNFL) defects and the degree of myopia in patients with normal-tension glaucoma (NTG). Methods. We retrospectively reviewed medical records of patients with high myopia (42 eyes; spherical equivalent [SE] < -6.0 diopters [D]), low to moderate myopia (93 eyes; SE -6.0D ∼ and -0.5D), and emmetropia (65 eyes; SE -0.5D ∼ +0.5D), all of which were diagnosed as having NTG with localized RNFL defects. On RNFL photographs, the proximity of the RNFL defect to the center of the fovea (angle I) and the sum of the angular width of the defects (angle II) were determined. The patterns of localized RNFL defects were then compared with respect to differences in angles I and II. Results: Angle I was significantly smaller in the high myopia group than in the low to moderate myopia group (p = 0.028) and the emmetropia group (p = 0.044), while angle II was significantly larger in the high myopia group compared with the low to moderate myopia group and the emmetropia group (p < 0.001, p = 0.007). Conclusions: Among subjects with NTG, localized RNFL defects are wider and closer to the fovea in eyes with high myopia than those with low to moderate myopia or emmetropia.

KW - Myopia

KW - Normal-tension glaucoma

KW - RNFL defect

KW - Refractive error

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U2 - 10.1186/1471-2415-13-67

DO - 10.1186/1471-2415-13-67

M3 - Article

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VL - 13

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